一个新的下丘脑-胰岛轴血糖调解系统激素分泌的非线性动力学模型

A new non-linear dynamics model of the pulsatile secretion of blood glucose regulation by hypothalamus-pancreatic island axis

提出了一个新的下丘脑-胰岛轴血糖调节系统激素分泌的非线性动力学模型.该模型能够合理地描述健康人群胰岛素、胰升糖素对血糖的调节作用以及这些激素随时间演化的动力学规律.仿真模拟口服葡萄糖耐量实验(OGTT)结果表明,该模型是一个更加符合人体生理实际的血糖调节模型.

The investigation put forward a hypothalamus-islet blood glucose regulation new hormone secretion nonlinear dynamic model of sys the regulating effect of blood glucose of healthy the kinetics law of endocrine hormone evolving （OGTT） results show that the blood glucose conformed to physiological facts of human. tern. The result of the model can reasonably describe population＇s insulin and glucagon. It can also obtain with time. The simulated oral glucose tolerance test accommodation model is a better one which is more