内镜下靛胭脂-美兰双重染色法诊断早期胃癌及癌前病变的临床价值分析

Clinical Value Analysis of Endoscopic Indigo Carmine-Methylene Blue Double Staining in Diagnosis of Early Gastric Cancer and Precancerous Lesions

目的:探讨内镜下靛胭脂-美兰双重染色法对诊断早期胃癌及癌前病变的临床应用价值。方法:来就诊患者行常规内镜检查,将有可疑病灶患者112例随机分为两组,观察组行内镜下靛胭脂-美蓝染色后活检,对照组采用后常规活检。结果:观察组(57例)分别检出早期胃癌16例、癌前病变27例。对照组(55例)分别检出早期胃癌9例、癌前病变19例,观察组与对照组早期胃癌和癌前病变检出率分别为43/57(75.4%)和28/55(50.9%),且差异有统计学意义(P<0.01)。有明显染色分界区28/57(49.1%)的胃癌和癌前病变的检出率均显著高于无明显染色分界区15/57(26.3%)(P<0.05)。结论:内镜下靛胭脂一美兰双重染色能显著提高早期胃癌和癌前病变的检出率,对早期胃癌和癌前病变诊断具有一定的指示意义。

Objective： To investigate clinical value of the endoscopic indigo carmine-methylene blue double staining in diagnosis of early gastric cancer and precancerous lesions.Methods：The patients to seek treatment with routine endoscopy, those of 112 suspicious lesions were randomly divided into two groups, the observation group were taken biopsy after endoscopic indigo carmine-methylene blue staining.The control group were routine biopsy.Results： 16 cases of early gastric cancer and 27 cases of precancerous lesions were detected in the observation group （57 cases）.9 cases of early gastric cancer and 19 cases of precancerous lesions were detected in the control group （57 cases）.The early gastric cancer and precancerous lesion positive rale of the observation group and the control group was 43/57 （75.4%）, and 28/55 （50.9%）, respectively.The difference was statistically significant （P〈0.01）.There are obvious staining demarcation zone 28/57 （49.1%） of gastric cancer and precancerous lesion detection rate was significantly higher than those without clear demarcation zone staining 15/57 （26.3%） （P〈0.05）.Conelusion： Endoscopic indigo carmine methylene blue double staining can significantly improve the detection rate of early gastric cancer and precancerous lesion,that has the certain instruction significance or the early diagnosis of gastric cancer and precancerous lesions.