高血压患者OGTT试验结果分析

Analysis of OGTT results in hypertension patients

目的探讨高血压与胰岛素抵抗的关系。方法 1133例做口服葡萄糖耐量试验(OGTT)的研究对象,排除360例不符合标准的患者后,剩余773例分为高血压(93例)与非高血压(680例)两组,再分别把体质量指数(BMI)<24 kg/m2视分为正常体重组,把BMI≥24 kg/m2定为肥胖组;OGTT试验中,检测各时相的血糖、胰岛素、C肽数值并进行统计分析。结果 BMI≥24 kg/m2的高血压或非高血压者,其血糖、胰岛素、C肽均值分别高于BMI<24 kg/m2者(P<0.05)。BMI<24 kg/m2的高血压与非高血压者对比,糖负荷后1.0 h高血压患者血糖显著高于非高血压者(P>0.05)。BMI≥24 kg/m2的高血压患者,除3.0 h血糖外,其余时相血糖、胰岛素、C肽与非高血压组比较,差异有统计学意义(P<0.05)。结论肥胖合并高血压患者有明显的"三高",即高血糖、高胰岛素、高C肽血症。

Objective To investigate relationship between hypertension and insulin resistance. Methods There were 1133 patients receiving oral glucose tolerance test（OGTT） as study subjects, and 360 unqualified cases among them were eliminated. The other 773 cases were divided into hypertension group（93 cases） and non-hypertension group（680 cases）. Patients with body mass index（BMI） 〈24 kg/m^2 were taken as normal weight group, and those with BMI ≥ 24 kg/m^2 as obesity group. Detections were made on blood glucose, insulin, and C-peptide in different time points for statistical analysis. Results Patients with BMI ≥ 24 kg/m^2 in both hypertension and non-hypertension groups had higher blood glucose, insulin, and C-peptide than those with BMI〈 24 kg/m^2（P〉0.05）. Patients with BMI〈 24 kg/m^2 in hypertension group had higher 1.0 h blood glucose after glucose load than those in non-hypertension group（P〈0.05）. Patients with BMI ≥ 24 kg/m^2 in hypertension group had statistically significant differences of blood glucose, insulin, and C-peptide with non-hypertension group, with exception of 3.0 h blood glucose（P〈0.05）. Conclusion Obesity complicated with hypertension patients have obvious high levels of blood glucose, insulin, and C-peptide.