鼻咽癌常规放疗与调强放疗远期并发症及疗效的对比分析

Late Complications and Efficacy of Conventional Radiotherapy and Intensity-modulated Radiotherapy for Nasopharyngeal Carcinoma

目的比较鼻咽癌常规放疗与调强放疗的远期并发症及疗效.方法将160例鼻咽癌患者分为常规放疗组和调强放疗组,回顾性分析两组患者治疗后远期并发症发生情况及生存情况.结果调强放疗组远期口干、颈部纤维化和放射性脑病发生率明显低于常规放疗组,差异具有显著性（P〈0.05）;两组患者远期张口受限、放射性龋齿和听力下降发生率比较,差异无统计学意义（P〉0.05）;两组1～3年生存率比较,差异无统计学意义（P〉0.05）;调强放疗组4～7年生存率均明显高于常规放疗组,差异具有显著性（P〈0.05）.结论调强放疗治疗鼻咽癌远期并发症发生率低于常规放疗,远期生存率高于常规放疗,远期疗效优于常规放疗.

Objective To compare the late complications and efficacy of conventional radiotherapy and intensity-modulated radiotherapy for nasopharyngeal carcinoma. Methods 160 cases of nasopharyngeal carcinoma were divided into the conventional radiotherapy group and the intensity-modulated radiotherapy group. The late complications and treatment results were analyzed retrospectively. Results There were significant difference in xerostomia,the incidence of neck fibrosis and radiation encephalopathy between the 2 groups( P < 0. 05); There was no significant difference in limited mouth opening,the incidence of dental caries,and hearing loss( P > 0. 05); There was no significant difference in 1 ~ 3 year overall survival rate between the 2groups( P > 0. 05); There were significant differences in 4-year overall survival rate and 7-year overall survival rate between the 2groups( P < 0. 05),and the IMRT group was higher than the conventional radiotherapy group. Conclusion Conclusion IMRT for nasopharyngeal carcinoma has fewer late complications,higher long-term survival and better long-term efficacy.