TSH、TG检测在甲状腺结节患者术前良恶性预测中的临床应用

Clinical application of detection of serum TSH and TG in the prediction of benign and malignant thyroid nodules in preoperative patients

目的探讨TSH、TG检测在术前甲状腺结节患者良恶性预测中的临床应用。方法回顾分析770例行甲状腺手术的甲状腺结节患者术前的TSH、TG水平和术后临床诊断等资料。然后按参考值将TSH、TG的阳性界限为≥4.94m IU/L和≥70 ng/m L,否则为阴性,将所有病例分为4组对比分析。结果发现甲状腺癌患者的术前血清TSH水平(5.96±4.81)m IU/L明显高于良性甲状腺结节患者(3.73±3.62)m IU/L,P<0.01;甲状腺癌患者术前TG水平(111.23±249.64)ng/L和良性甲状腺结节患者术前TG水平(86.79±178.85)ng/L比较,差异无统计学意义(P>0.05);甲状腺癌患者的TSH和TG无相关性,P>0.05;TSH、TG双阳性组中甲状腺癌比例最高,和其他三组相比差异具有统计学意义(P<0.05)。结论 TSH、TG同时增高呈阳性可作为判断甲状腺肿瘤良恶性的一个辅助指标。

Objective To explore clinical application of detection of serum TSH and TG in the prediction of benign andmalignant thyroid nodules in preoperative patients. Methods Levels of serum TSH and TG in770 cases undergoingthyroidectomy were detected and their postoperative data were retrospectively analyzed.Reference range of TSH,TG was ≥4.94 m IU/L and ≥ 70ng/m L,levels out of this range were taken as negative. All the patients were divided into 4 groups for analysisand comparison. Results The level of serum TSH in thyroid cancer patients before operation was significantly higher thanthat in patients with benign thyroid nodules [（5.96±4.81 vs 3.73±3.62）m IU/L,t=6.683,P〈0.01];Preoperative levels of serumTG in thyroid cancer patients were not significant compared to patients with benign thyroid nodules [（111.23±249.64 vs 86.79±178.85）ng/l,t=1.54,P〉0.05）];No correlation was observed between the levels of serum TSH and TG in thyroid cancerpatients（P〉0.05）;Proportion of thyroid cancer patients both positive for TSH and TG was higher than that of other three groups（P〈0.05）.Conclusion Simultaneous increasing of serum TSH and TG can be used as an auxiliary index in judgement ofbenign and malignant thyroid tumors.