猪瘟病毒核心蛋白研究进展

Research Progress in the Core Proteins of the Classical Swine Fever Virus

核心蛋白是猪瘟病毒(Classical swine fever virus,CSFV)的结构蛋白之一,除了构成病毒核衣壳保护内部的基因组RNA外,还参与转录调节,并可和多种宿主蛋白相互作用,在病毒感染过程中发挥重要作用。本文结合当前对CSFV核心蛋白的无序性,结构特点,功能特点,以及和病毒的非结构蛋白NS3、NS5B,宿主蛋白SUBMO-1、UBC9、OS9、IQGAP1相互作用的研究,综述了CSFV核心蛋白在猪瘟病毒致病力、毒力和基因组RNA复制中发挥的重要作用,以期为CSFV核心蛋白的进一步研究提供参考。

The core protein （CP） of the classical swine fever virus （CSFV） is one of its structural proteins. Apart from forming the nucleocapsid to protect internal viral genomic RNA, this protein is involved in transcriptional regulation. Also, during viral infection, the CP is involved in interactions with many host proteins. In this review, we combine study of this protein with its disorders, structural/functional charac- teristics, as well as its interactions with the non-structural proteins NS3, NS5B and host proteins such as SUMO-1, UBC9, OS9 and IQGAP1. We also summarize the important part played by the CP in CSFV pathogenicity, virulence and replication of genomic RNA. We also provide guidelines for further studies in the CP of the CSFV.