孟鲁司特钠联合平喘止咳贴治疗儿童咳嗽变异性哮喘60例疗效观察

Observation of clinical effectiveness of Montelukast combined with Pingchuan Zhike Tie in the treatment of 60 children with cough variant asthma( CVA)

目的观察孟鲁司特钠联合平喘止咳贴治疗儿童咳嗽变异性哮喘(CVA)的疗效及安全性。方法116例CVA患儿随机分为治疗组60例和对照组56例,治疗组给予口服孟鲁司特钠联合平喘止咳贴贴敷,对照组仅给予孟鲁司特钠口服,8周后观察2组的疗效。结果治疗组总有效率为83.3%,对照组为76.8%,经统计学分析,差异有统计意义(P<0.05)。治疗后治疗组患儿的日间咳嗽症状评分、夜间咳嗽症状评分均较治疗前及对照组患儿明显改善,差异有统计意义(P<0.05)。结论孟鲁司特钠联合平喘止咳贴治疗CVA能够明显提高疗效,且应用安全,值得临床推广应用。

Objective To investigate the clinical effectiveness and safety of Montelukast combined with Ping- chuan Zhike Tie in the treatment for cough variant asthma （CVA） in children. Methods The 116 cases of CVA outpatients were randomly divided into the treatment group （n = 60） and the control group （n = 58 ）. The treatment group were given Montelukast and Pingchuan Zhike Tie, while the control group were only given Montelukast. The clinical effectiveness of the two groups was analyzed after 8-weeks treatment. Results After treatment, the total effective rate of treatment group was 83.3% ,while that of the control group was 76.8%, the efficient of the treatment group was obviously higher than the control group （P〈0.05）. After treatment, patients＇ daytime cough symptom seores and night cough symptom scores improved significantly compared with those of pre-treatment and patients in the control group, and the difference of two groups was statistically significant （P〈0.05）. Conclusion The treat- ment of Montelukast combined with Pingchuan Zhike Tie for CVA showed better clinical effectiveness and safety, whieh could be recommended for clinical application and promotion.