泄泻合剂灌肠治疗小儿轮状病毒性腹泻湿热型42例临床观察

The clinical effect of enema treatment of Xiexie Heji in the treatment of 42 cases infantile rotavirus enteritis of damp-heap type

目的观察泄泻合剂灌肠治疗小儿轮状病毒性腹泻湿热型的临床疗效及发病机制。方法选择符合轮状病毒性腹泻湿热型诊断标准的患儿83例,随机分为2组。治疗组42例予基础治疗加泄泻合剂灌肠治疗,对照组41例予基础治疗加思密达治疗。治疗3 d后,比较2组的临床疗效及大便分泌型IgA(sIgA)的变化。结果治疗组总有效率为95.24%,对照组为80.49%,2组比较差异有统计意义(P<0.05)。治疗组治疗后平均止泻时间为(2.41±0.37)d,对照组为(3.55±0.43)d,2组平均止泻时间比较,差异有统计意义(P<0.05)。2组治疗前后大便sIgA比较,差异均有高度统计意义(P<0.01);2组治疗后组间比较,差异有统计意义(P<0.05)。结论患儿患轮状病毒肠炎时,大便sIgA水平下降,泄泻合剂灌肠能激发肠道组织产生更多的s Ig A,加快清除病毒,且治疗过程中未发现病情加重、皮疹等情况,值得在临床中推广使用。

Objective To investigate the clinical efficacy of enema treatment of Xiexie Heji in the treatment of infantile rotavirus enteritis of damp-heap type and the pathogenesis of the disease. Methods 83 cases of children with rotavirus diarrhea of damp-heat type were randomly divided into two groups. The 42 cases in the treatment group were given basic therapy plus enema treatment of Xiexie Heji, the 41 cases in the control group were given basic therapy plus montmorillonite powder. After treatment of 3 days, the clinical efficacy and fecal sIgA were com- pared between the two groups. Results The total effective rate of the treatment group was 95.24% and that in the control group was 80.49% , the difference was statistically significant （P〈0.05）. The average time of diarrhea of the treatment group was （2.41_＋0.37） days, the control group was （3.55_＋0.43） days, there was statistically sign- ficant between two groups （P〈0.05）. A comparison was made of fecal sIgA before and after treatment and the difference was highly statistically significant （P〈0.01）. A comparison was made between the two groups after treatment and the difference was statistically significant （P〈0.05）. Conclusion In rotavirus enteritis the fecal sI- gA level dropping, the enema treatment of Xiexie Heji can stimulate the intestinal tissues to produce more sIgA to accelerate the removal of viruses, and the Xiexie Heji enema is safe, with the rash being not found during the treat- ment, worth promoting in clinical use.