摘要
目的研制微粉化双黄朴水凝胶贴剂,并观察其体外释药性能及透皮吸收特点。方法以水溶性高分子材料为辅料制备微粉化双黄朴水凝胶贴剂;高效液相色谱法测定小檗碱的经皮吸收量,按《中华人民共和国药典》2010年版要求进行体外释放度测定,采用改良的Franz扩散池法研究水凝胶贴剂的经皮吸收特点。结果水凝胶贴剂含药量稳定,体外释药符合Higuchi分布方程,水凝胶贴剂中的小檗碱在12 h内透皮为零级过程,释放速率是7.934μg·(cm2)-1·h1/2,透皮速率为0.571μg·(cm2)-1·h-1。结论微粉化双黄朴水凝胶贴剂为一种新型控释型经皮给药制剂。
Objective To study preparation of micronized Shuanghuangpo hydrogel patch and its characteristics of transdermal penetration in vitro. Methods Micronized Shuanghuangpo hydrogel patch was prepared with some macromolecular water-soluble materials as gel base.The content of berberine was determined by HPLC method.Its transdermal penetration in vitro was determined according to the method of Chinese Pharmacopoeia 2010 edition. The rat skin penetration test in vitro was performed by modified Franz diffusion cell method. Results The hydrogel patch had constant content of berberine. Its release property in vitro conformed to Higuchi equation. The penetration of berberine in the hydrogel patch through the rat skin followed zero-order dynamics in 12 h.Its release rate was 7.934μg·（cm2）-1·h1/2 and percutaneous rate was 0.571μg·（cm2）-1·h-1. Conclusion The micronized Shuanghuangpo hydrogel patch is a new transdermal agent with sustained release property.
出处
《医药导报》
CAS
2015年第10期1339-1342,共4页
Herald of Medicine
基金
上海市卫生局中医药科研基金资助项目(2012Y012B)
关键词
微粉化双黄朴
水凝胶贴剂
小檗碱
释放
体外
透皮
Micronized Shuanghuangpo
Hydrogel patch
Berberine
Release, in vitro
Transdermal penetration
