宫颈癌灶血管化程度与术后病理学指标的关系研究

Correlation between vascularization level and postoperative pathological factors in cervical cancer

目的探讨ⅠB1-ⅡA2期宫颈癌灶血管化程度与术后病理学指标之间的相关性。方法收集2009年1月至2015年1月就诊于南方医科大学南方医院术前行腹盆腔三维CT血管造影术（CTA）扫描的FIGO分期ⅠB1-ⅡA2期宫颈癌手术病例135例，进行子宫动脉血管网数字化三维重建，并立体分割计算宫颈与宫体动脉血管网体积。根据两部分体积之比由低到高分为4个宫颈癌灶血管化程度类型。分析血管化程度与术后病理学指标之间的相关性。结果宫颈癌灶血管化程度与宫颈浸润深度（P=-0．014）和宫旁浸润（P=0．001）相关。宫颈癌灶血管化程度与FIGO临床分期以及其他术后病理学指标无相关性（D，0．05）。结论宫颈癌灶血管化程度增高可能作为术前判断宫旁浸润以及宫颈深肌层浸润的高危因素之一。

Objective To estimate the correlation between the vascularization level and postoperative pathological factors in cervical cancer of FIGO stage ⅠB1-ⅡA2. Methods The preoperative data of computed tomography angiography （CTA） and postoperative pathology results of 135 cases of FIGO stage ⅠB1-ⅡA2 cervical cancer, who conducted operation straightly in Nanfang Hospital from Jan 2009 to Jan 2015, were collected. The uterine artery network model of each case was reconstructed and divided, and the ratio of the volume of arteries of cervix and corpus were calculated. Four types were defined based on this ratio. The statistical correlation between the vascularization level and the postoperative pathological factors was analyzed. Results The vascularization level of cervical cancer was correlated with depth of invasion （P=0.014） and parametrial invasion （P=0.001）. The vascularization level was not correlated with FIGO stage or other pathological factors （P〉0.05）. Conclusion The high level of vascularization in cervical cancer may be considered as a high risk factor of deep invasion of cervix and parametrial invasion.