结直肠息肉患者高脂血症血脂分析

Analysis of hyperlipidemia in patients with colorectal polyps

目的观察和比较结直肠息肉患者的血脂水平。方法入选2011年1月至2014年1月于我院就诊的结直肠息肉患者120例作为研究观察对象，选择同期健康体检者120名为健康对照组，检测两组受试者血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）浓度，同时比较结直肠息肉病理类型、部位、性别等亚组的血脂水平。结果观察组患者中单发息肉81例，多发息肉39例，全结直肠息肉7例；其中高脂血症53例，占44．17％。结直肠息肉患者TC、TG和LDL—c水平分别为（5．26±0．97）mmol／L与（1．55±0．59）mmol／L与（2．88±0．67）mmol／L，健康对照组为（4．51±1．02）mmol／L与（1．05±0．57）mmol／L与（2．43±0．39）mmol／L，观察组高于健康对照组，差异均有统计学意义（t值分别为4．08、4．27、3．87，P均〈0．05）；不同病理类型高脂血症发病率差异无统计学意义（P〉0．05）；各病理类型血脂水平比较差异无统计学意义（P均〉0．05）；进一步分析腺瘤性息肉亚组结果，显示管状绒毛状腺瘤高脂血症发病率明显高于管状腺瘤和绒毛状腺瘤，差异有统计学意义（χ2=4．51，P〈0．05），但血脂水平组问差异无统计学意义（P均〉0．05）；结直肠息肉发病情况与TC、TG、LDL-C水平、性别等因素密切相关（95％C1分别为1．695～5．276、1．823～3．517、1．634—4．186，P均〈0．05）。结论结直肠息肉患者TC和TG升高，临床诊断和治疗应当注意对血脂水平的检测和评估。

Objective To observe and compare the blood lipid level in patients with colorectal polyps. Methods One hundred and twenty patients with eoloreetal polyps adminated in Shuangshan Hospital ofAnshan from January 2011 to January 2014 were selected as observations and 120 healthy check-ups were selected as control group. The levels of serum total cholesterol （TC）, triglyceride （TG） and low density lipoprotein cholesterol（ LDL-C ） of two groups were detected. Based on the pathological type and position of colorectal polyps and patients＇ gender, the blood lipid levels of sub-groups were compared. Results For observation group ,there were single polyps in 81 cases, multiple polyps in 39 cases and total colorectal polyps in 7 cases. There were 53 cases （44. 17%） of hyperlipidemia （HLP）. The levels of TC, TG and LDL-C of observation group were （ 5.26 ± 0. 97 ） mmol/L, （ 1.55 ± 0. 59 ） mmol/L, （ 2. 88 ± 0. 67 ） mmol/L, significantly higher than those of control group （ （4. 51±1.02） mmol/L, （ 1.05±0. 57） mmol/L, （2.43±0. 39） mmol/L;t =4.08,4.27, 3.87, P〈0.05）.the incidence of HLP based on the different pathological types were not significantly changed （P 〉 0. 05 ）. The blood lipid levels based on the different pathological types were not significantly changed （P〉0. 05 ）. According to analysis results of adenomatous polyp, the incidence of tubular and villous adenoma HLP was significantly higher than that of tubular and villous adenoma（ χ2 = 4. 51, P〈0. 05 ） , while there was no significant difference in term of the blood lipid levels between the two groups （P〉0. 05 ）. The specific blood lipid levels were different （ 95% CI 1. 695 - 5. 276, 1. 823 - 3.517, 1. 634- 4. 186; P 〈0. 05）. Conclusion TC and TG increase in patients with colorectal polyps. The clinical diagnosis and treatment shall focus on the detection of blood lipid levels.