乳腺浸润性导管癌EGFR、CK 5/6表达及临床意义分析

Analysis the Clinical Significance of Breast Infiltrating Ductal Carcinoma EGFR, CK 5/6 Expression

目的：探讨乳腺浸润性导管癌DEFR、CK5/6的表达情况及其临床应用价值。方法选取我院2013年6月～2014年6月收治的乳腺浸润性导管癌的患者102例作为研究对象，所有患者均经手术病理证实，并有完整的免疫组化法病理检测结果。回顾性分析患者的基本资料、EGFR和CK5/6表达情况。结果102例乳腺导管浸润癌患者中，EGFR和CK5/6的阳性表达率分别为27.5%和22.5%，二者的共同表达率为77.5%（79/102），χ2=5.871，P＞0.05，差异不具有统计学意义，EGFR和CK5/6的表达具有一致性。EGFR和CK5/6在三阴性乳腺癌中的表达率均高于在非三阴性乳腺癌中的表达率，P＜0.05，差异具有统计学意义。结论通过对乳腺浸润性导管癌DEFR、CK5/6的表达情况进行分析，可以为患者的病变程度进行判断，为患者的治疗、预后评估提供可靠依据。

Objective To explore the clinical value of DEFR breast invasive ductal carcinoma, the expression of CK 5/6 cases. Methods Selected 102 cases of patients with infiltrating ductal carcinoma from June 2013 to June 2014 as the research object, all patients were confirmed by surgery pathology, has a full set of immunohistochemical method and pathological results. Patients were retrospectively analyzed, the basic information, EGFR and CK 5/6 expression.Results102 cases of mammary gland carcinoma inifltrating carcinoma patients, EGFR and CK 5/6 positive expression rate of 27.5% and 22.5%, respectively, of the two common expression rate was 77.5% （ 79/102 ）, χ2=5.871,P〉0.05, had no difference statistically significance, the expression of EGFR and CK 5/6 with consistency. EGFR and CK 5/6 in three negative expression rate of breast cancer were significantly higher than in the three negative expression rate of breast cancer,P〈0.05, had difference statistically significance.Conclusion Through the DEFR breast invasive ductal carcinoma, the expression of CK 5/6 cases were analysis, and for the degree of pathological changes in patients with judgment, provide reliable basis for treatment and prognosis evaluation of patients.