EMT相关分子标志物在胆管癌侵袭转移中的研究进展

Epithelial mesenchymal transition related molecular markers and invasion and metastasis of cholangiocarcinoma

肿瘤转移是导致实体瘤患者死亡的主要原因.上皮-间质转化(epithelial mesenchymal transition,EMT)是上皮细胞转化为间质细胞伴随基因和表型改变的过程,在肿瘤发生侵袭和转移过程中常常被激活.胆管癌是起源于胆道上皮的一种恶性肿瘤,早期易浸润、转移和复发是其主要生物学特点.研究胆管癌的转移机制能够为未来治疗胆管癌的新方法,建立新的治疗策略提供理论依据.本文综述了近年来EMT相关标志物,包括细胞表型分子标志物及EMT相关调控因子与胆管癌浸润转移的研究进展.

Tumor metastasis is a major cause of death in patients with solid tumors. Epithelial mesenchymal transition （EMT） is a process in which the epithelial cells are transformed into the stroma cells. This process is accompanied by changes in gene expression and cell phenotype, which are often activated during tumor invasion and metastasis. Cholangiocarcinoma is a kind of malignancy originating from the bile duct epithelium, and its main biological characteristics are early invasion, metastasis and recurrence. The research of cholangiocarcinoma metastasis could provide a theoretical basis for the development of new treatment strategies to manage this malignancy. This paper reviews the roles of EMT related molecular markers metastasis in the invasion and metastasis of cholangiocarcinoma.