超声实时剪切波弹性成像对健康成人进餐前后肝脏的杨氏模量值变化

Shear wave elasticity imaging for measuring hepatic Young's modulus values in healthy adults before and after meals

目的:通过超声实时剪切波评估正常成人肝杨氏模量值是否受进餐的影响.方法:利用超声实时剪切波弹性成像(realtime shear wave elastography,SWE)技术分别测量158例健康志愿者空腹(8 h以上)、餐后1 h、餐后2 h肝脏杨氏模量值,分析进餐对肝杨氏模量值的影响.所有受检者均在同一条件下接受3次测量并求平均值进行统计学分析.结果:158例受检者中有154例获得成功,成功率为97.5%.餐前正常肝杨氏模量均值为5.89 k Pa±0.92 k Pa,95%可信区间(95%confidence interval,95%CI)为4.88-7.21 k Pa;餐后1 h肝脏杨氏模量均值为6.09 k Pa±1.05k Pa,95%CI为5.00-7.55 k Pa;餐后2 h肝杨氏模量均值为5.95 k Pa±1.10 k Pa,95%CI为4.75-7.48 k P a.经统计学分析,患者在进餐前后的肝脏杨氏模量均值变化均无统计学意义(P>0.05),而餐后2 h与餐后1 h最大值及餐后2 h与餐前最小值比较有统计学意义(P<0.05).结论:通过SWE技术对正常人进食前后肝杨氏模量值进行测量的结果说明其弹性变化不受进餐影响,可进行稳定重复.

AIM： To explore the effect of meals on hepatic Young＇s modulus by shear wave elasticity imaging. METHODS： The Young＇s modulus values of 158 healthy volunteer were measured at fasting （over 8 h）, 1 h and 2 h after meals using real-time shear wave elastography to analyze the effect of meals on hepatic modulus values. All subjects were measured in the same conditions. RESULTS： The measurements were successful in 154 of 158 （97.5%） subjects. The modulus before meals was 5.89 kPa ± 0.92 kPa [95% confidence interval （CI）： 4.88-7.21 kPa]; the values at 1 h and 2 h after meals were 6.09 kPa ± 1.05 kPa （95%CI： 5.00-7.55 kPa） and 5.95 kPa ± 1.10 kPa （95%CI： 4.75-7.48 kPa）, respectively. Statistical analysis showed that the change in hepatic modulus values before and after meals had no statistical significance （P 〉 0.05）, although statistical significance was noted in the maximum value between 2 h and I h after meals and the minimum value between before meals and 2 h after meals （P 〈 0.05）. CONCLUSION： Meals have no influence on modulus values in healthy adults.