吉兰-巴雷综合征患者血浆置换与注射免疫球蛋白治疗的疗效比较

Comparison on therapeutic effect of plasma exchange and Intravenous Immunoglobulin for Guillian-Barre Syndrome

目的分析血浆置换(PE)与静脉注射免疫球蛋白(IVIg)在治疗吉兰-巴雷综合征(GBS)的过程中临床疗效的差异。方法 64例GBS患者分别进行PE与IVIg治疗,观察治疗前及治疗后患者神经功能改善状况。结果 PE治疗的GBS患者神经功能改善情况优于IVIg组,且临床效果显现时间早于IVIg组,治疗2 w后两组的有效率分别是96%和79%,PE治疗效果优于IVIg组。结论 PE可有效改善患者症状,有利于患者病情的早期康复。

Objective To observe and compare the clinical curative effect of the plasma exchange （PE） and Intra- venous Immunoglobulin （IVlg） for Guillian-Barrc Syndrome （GBS）. Methods Overall, 64 adult patients with GBS for PE and IVIg treatment, respectively, and nerve function were observed pre-treatment and at 1 week/2 weeks after completion of treatment. Results After plasma exchange treatment,nerve function appeared to improve better than the IVlg group and clinical effect was better than the IVIg group. Treatment effective rates of the two groups after 2 weeks, respectively, were 96% and 79%. The curative effect of PE were better than the IVIg group. Conclusion PE treatment has a more signifi- cantly curative effect, as it can effectively improve symptoms and be helpful in the early rehabilitation of patients.