预知子化学成分研究

Chemical Constituents from the Fruits of Akebiae quinata

目的研究预知子[Akebia trifoliate（Thunb）koidz]的化学成分。方法采用柱色谱和半制备液相色谱进行分离，利用化合物的光谱数据结合理化性质鉴定化合物的结构。结果分离鉴定了15个化合物，分别为京尼平苷酸（1）、10-乙酰基京尼平苷酸（2）、3-氧化-6-羟基紫罗兰醇（3）、对羟基苯甲酸（4）、原儿茶酸（5）、咖啡酸（6）、酪醇（7）、棕榈酸（8）、15-二十九烷醇（9）、豆甾醇（10）、豆甾醇-3-O-β-D-吡喃葡萄糖苷（11）、β-谷甾醇（12）、β-胡萝卜苷（13）、熊果酸（14）和齐墩果酸（15）。结论化合物1～7，9，14为首次从预知子中分离得到。

OBJECTIVE To study the chemical constituents of the fruits of Akebiae quinata. METHODS Various column chro- matography techniques including silica gel, Sephadex LH -20, and macroporous adsorption resin column chromatography were used for fractionization and purification. The structures were identified on the basis of their physicochemical and spectroscopic evidence. RE- SULTS Fifteen compounds were obtained, and their structures were identified as geniposidic acid（ 1 ） , 10-O-acetylgeniposidic acid （2）, vomifoliol（3）, p-hydroxybenzoic acid（4）, protocatechuic acid（5）, caffeic acid（6）, tyrosol（7）, palmitic acid（8）, 15-nona- cosanol（9）, stigmasterol（10）, stigmasterol-3-O-,β-D-glycopyranoside（11）, β-sitosterol（ 12）, β-daucosterol（13）, ursolic acid（14）, and oleanolic acid（15）. CONCLUSION Compounds 1 -7, 9 and 14 were isolated from the fruits of Akebiae quinata for the first time.