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靶向生长抑素受体正电子显像剂的临床研究进展 被引量:6

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摘要 天然生长抑素是一种含有14个或28个氨基酸的多肽类激素,在体内很容易被酶降解,且在人体内生物半衰期较短(2-3 min),限制了其临床应用。奥曲肽(octreotide,OC)是对天然生长抑素进行人工修饰合成的八肽,肽序列为D-PheCys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol),其结构中引入D型氨基酸,增强了抵抗酶降解的能力,在体内作用时间可达2 h。
出处 《中国医学影像学杂志》 CSCD 北大核心 2015年第8期627-631,共5页 Chinese Journal of Medical Imaging
基金 广东省自然科学基金项目(S2012010010685) 广东省教育部产学研结合项目(1212225700004)
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