摘要
目的:系统评价巴西蘑菇的免疫调节效应。方法:全面检索了Pubmed、Embase、CENTRAL、Sino Med、CNKI和万方等电子数据库,纳入了以巴西蘑菇为干预、安慰剂或空白为对照、关注了免疫相关结局的随机对照试验,采用随机效应模型进行了Meta分析。结果:获得了6项合格研究;与安慰剂或空白对照相比,巴西蘑菇在免疫球蛋白、NK细胞活性、白细胞计数和淋巴细胞计数结局上的均差分别为3.27g/L、7.39%、1.44×109/L、-0.02×109/L,未发现巴西蘑菇对IL-6、TNF-α和IFN-γ结局的影响。结论:现有证据支持巴西蘑菇在免疫球蛋白和NK细胞活性上的免疫调节效应。今后需要开展大样本、方法学质量高、长期随访的随机对照试验。
[Objective] To systematically evaluate the immunomodulating effect of Agaricus blazei. [Method] Electronic database in- cluding Pubmed, Embase, CENTRAL, SinoMed, CNKI and Wanfang were searched. Randomized controlled trials comparing the effect of Agaricus blazei with placebo/blank control on immunological outcomes were included. The random-effects model was used to conduct Meta-a- nalysis. [Result] Totally 6 eligible studies were included. The pooled mean differences in immunoglobulin, NK cell activity, WBCs count and lymphocytes count between Agaricus blazei and placebo/blank control groups were 3. 27g/L, 7. 39% , 1.44 ×10^9/L, and - 0. 02 ×10^9/L, respectively. No effects of Agaricus blazei on IL-6, TNF-α and IFN-γ were found. [Conclusion] Current evidence supported immu- nomodulating effect of Agaricus blazei on immunoglobulin and NK cell activity. In the future, large randomized controlled trials with high methodological quality and long-term follow-up were needed.
出处
《中国食物与营养》
2015年第9期63-66,共4页
Food and Nutrition in China
