热毒宁治疗小儿手足口病随机平行对照研究

Randomized Parallel Group Study of Foot and Mouth Disease in Children Reduning Treatment

[目的]观察热毒宁治疗小儿手足口病疗效。[方法]使用随机平行对照方法,将100例门诊及住院患者按病志号抽签法简单随机分为两组。物理降温、保持水电解质的平衡。对照组50例利巴韦林8mg/kg+5%葡萄糖250m L,1次/d,静滴。治疗组50例热毒宁0.7m L/kg+5%葡萄糖250m L,1次/d,静滴。连续治疗5d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈22例,显效16例,有效10例,无效2例,总有效率96.00%。对照组痊愈18例,显效6例,有效15例,无效11例,总有效率78.00%。治疗组疗效优于对照组(P<0.01)。时间指标治疗组改善优于对照组(P<0.01)。[结论]热毒宁治疗小儿手足口病疗效满意,无严重不良反应,值得推广。

[Objective]To observe the effect Reduning treat pediatric foot and mouth disease.[Methods]Randomized parallel controlled method,100 outpatients and inpatients by disease Zhi No.lottery method is simple and randomly divided into two groups.Physical cooling,maintaining water and electrolyte balance.The control group of 50 patients 8mg/kg Ribavirin Injection ＋ 250 m L 5% glucose,1 times/d,intravenous infusion.Treatment group of 50 patients 0.7m L/kg Reduning injection ＋ 250 m L 5% glucose,1 times/d,intravenous infusion.5d continuous treatment course of treatment.Observation of clinical symptoms,herpes,adverse reactions.One course of treatment,to determine efficacy.[Results]The cure 22 cases,16 cases markedly effective in 10 cases,2 cases,the total efficiency of 96.00%.The control group cured 18 cases,effective in 6 cases,effective in 15 cases,11 cases,the total efficiency of 78.00%.Treatment group than the control group（P〈0.01）.Time Indicator treatment group than the control group improved（P〈0.01）.[Conclusion]Reduning treatment efficacy of pediatric foot and mouth disease were satisfactory,no side effects,worthy of promotion.