解毒散结消瘿汤联合左旋甲状腺素治疗桥本甲状腺炎随机平行对照研究

Jiedu Sanjie Xiaoying Detoxification combined with Western Medicine Treated Hashimoto's Thyroiditis Randomized Controlled Study

[目的]观察解毒散结消瘿汤联合左旋甲状腺素治疗桥本甲状腺炎疗效。[方法]使用随机平行对照方法,将36例门诊及住院患者按病志号抽签法简单随机分为两组。对照组16例左旋甲状腺素,1.6-1.8μg/kg·d-1,3次/d。治疗组20例解毒散结消瘿汤（夏枯草12g,桔梗8g,重楼、莪术、穿山龙、薄荷各10g,白芍18g,柴胡12g,玄参、鳖甲醋、浙贝母各10g,牡蛎煅20g,甘草6g）,1剂/d,水煎200m L,早晚口服;西药治疗同对照组。连续治疗28d为1疗程。观测临床症状、TGAb、TMAb、TSH、FT3、FT4、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组显效15例,有效4例,无效1例,总有效率95.00%。对照组显效8例,有效3例,无效5例,总有效率68.75%。治疗组疗效优于对照组（P〈0.05）。血液及生化指标两组均有改善（P〈0.05）,治疗组改善优于对照组（P〈0.05）。[结论]解毒散结消瘿汤联合左旋甲状腺素治疗桥本甲状腺炎疗效满意,无严重不良反应,值得推广。

[Objective]To observe Jiedu Sanjie Xiaoying Detoxification combined with western medicine Hashimoto＇s thyroiditis effect.[Methods]Randomized parallel controlled method,36 outpatients and inpatients by disease Zhi No.lottery method is simple and randomly divided into two groups.L-thyroxine tablets 16 cases in the control group,1.6-1.8μg/kg·d-1,3 times/d.Treatment group,20 patients detoxification Sanjie Xiaoying soup（Xiakucao 12 g,Jiegeng 8g,Chonglou,E＇zhu,Chaunshanlong,Bohe 10 g,Baishao 18 g,Chaihu 12 g,Xuanshen,Biejia,Zhebeimu each 10 g,Muli 20 g,Gancao 6g）,1/d,decoction 200 m L,sooner or later orally;Western medicine with the control group.28 d for a course of continuous treatment.Observation of clinical symptoms,TGAb,TMAb,TSH,FT3,FT4,adverse reactions.Continuous treatment of 3 courses,to determine efficacy.[Results]The treatment group 15 cases,effective in 4 cases,1 case,the total efficiency of 95.00%.8 cases in the control group,effective in 3 cases,5 cases,the total efficiency of 68.75%.Treatment group than the control group（P〈0.05）.Blood and biochemical parameters improved in both groups（P〈0.05）,treatment group was better than that in the control group（P〈0.05）.[Conclusion]Jiedu Sanjie Xiaoying Detoxification combined with western medicine Hashimoto＇s thyroiditis results were satisfactory,no side effects,worthy of promotion.