摘要
报告2例多年前曾意外发生农药林丹中毒(在同一实验室工作时发生),分别于中毒后第23年、26年确诊多发性骨髓瘤。血清有机氯农药及代谢产物水平与乳腺癌、子宫颈癌、子宫肌瘤发病率呈正相关;有些农药具有类似生物体激素性质,扰乱生物体内分泌系统作用。农药致癌发病率上升可能包括DNA损伤,损伤基因的固定和增殖,包括内分泌干扰物影响,影响免疫功能等。多发性骨髓瘤发生、发展与肺、肾密切相关,肺金受损,波及肾水,母病及子。化疗同时联合中药内服,补益肺肾、活血解毒、增效减毒。挖掘中西医综合诊疗,为多发性骨髓瘤研究提供新的思路,为预防医学提供新的参考信息。
The early stage of pesticide poisoning in Lin Dan was respiratory system and nervous system,and 2 patients hadmultiple bone tumors in many years.The levels of organochlorine pesticides and metabohtes in serum were positively correlated with the incidence of breast cancer, cervical cancer, and uterine fibroids.Pesticide cancer incidence rises may include DNA damage and genetic damage of fixed and proliferation,including effects of endocrine disrupting chemicals affect immune function.The occurrence and development of multiple myeloma are closely related to the lung and kidney,and the damage to the hmg is affected. At the same time,chemotherapy combined with Chinese medicine,invigorating lung and kidney,blood detoxification,toxicity.To provide new ideas for the research of multiple myeloma,and provide a new reference for preventive medicine.
出处
《实用中医内科杂志》
2015年第9期140-141,共2页
Journal of Practical Traditional Chinese Internal Medicine
关键词
农药林丹中毒
发多发性骨髓瘤
虚劳
骨痹
增效减毒
pesticide Lin Dan poisoning
multiple myeloma
deficiency
bone paralysis
synergistic reduction
