1992～2007年多省市队列人群女性血脂水平的变化特点

The changes of serum lipid from 1992 to 2007 in women from Chinese multi-provincial cohort study

目的：描述1992~2007年多省市队列研究中女性人群血脂水平的变化和特点。方法：1992年在多省市35~64岁人群中进行了基线危险因素调查,并建立了心血管病研究队列,平均年龄为（45.1±7.5）岁。2007年该队列人群组织了危险因素再调查,平均年龄（60.1±7.5）岁。对两次调查资料完整的2 949例女性调查结果进行分析。结果：11992~2007年,女性平均总TC、LDL-C和TG水平分别增加了0.80mmol/L、0.73mmol/L和0.53mmol/L。高TC（≥6.22mmol/L）、高LDL-C（≥4.14mmol/L）和高TG（≥2.26mmol/L）患病率均呈增加变化;其增加幅度分别为316.7%、293.2%和192.1%。2随着年龄增加,各年龄组女性平均TC水平、LDL-C水平和TG水平均呈上升变化;在60~69岁年龄组均值水平最高,高脂血症患病率最高;年龄≥70岁以后,血脂水平未见继续增加变化。3 1992年和2007年相同年龄组（50~64岁）比较结果显示：平均TC、LDL-C和TG水平分别增加了0.42mmol/L、0.75 mmol/L和0.32 mmol/L。高TC、高LDL-C和高TG血症检出率分别增加了9.9%、8.6%和10.3%。结论：从1992年到2007年,多省市队列研究中女性人群的血脂水平呈不良变化;在女性60~69岁年龄组TC、LDL-C和TG平均水平达到最高值。

Objective： To describe the changes of serum lipid and the prevalence of hyperlipidemia from 1992 to 2007 in the female population from Chinese Multi provincial Cohort Study（CMCS）. Methods： CMCS database were established on participants aged 35 - 64 （45.1 ± 7.5 ） years from 11 provinces during baseline examination on cardiovascular risk factors in 1992. Participants were followed up and invited to re-examine risk factor in 2007. Two thousand nine hundred forty and nine female participants with complete data from these two examinations were included in this study for investigating the changes of serum lipid. Results： （1） From 1992 to 2007, the mean level of total cholesterol （ TC ）, low-density lipoprotein cholesterol （ LDL-C ） and triglyceride （TG） increased 0. 80mmol/L, 0. 73mmo1/L and 0. 53mmol/L in respectively. The prevalence of hypercholes- terolemia （ ≥6. 22mmol/L）, high LDL-C （ I〉4. 14mmol/L） and hypertriglyceridemia （ ≥2. 26mmol/L） in- creased 15.2% , 12. 9% and 14. 6% , respectively. （2） With the increase of women age, the mean level of TC, LDL-C and TG increased, the greatest level of TC, LDL-C and TG were observed in the 60-69 year age group. （3） In the year 2007 compared to 1992, the mean level of TC, LDL-C and TG increased 0. 42mmol/L,0. 75 mmol/L and O. 32 mmol/L for the same age group （50-64 year）, the prevalence of hyperoholesterol-emia, high LDL-C and hypertriglyceridemia increased 9. 9%, 8.6% and 10. 3% respectively. Conclusion： From 1992 to 2007, the mean level of TC, LDL-C and TG increased in women. The greatest increases in TC, LDL-C and TG were observed in women 60-69 year age group.