ABO血型与急性心肌梗死的相关性分析

Association between ABO blood group and acute myocardial infarction

目的 研究ABO血型与急性心肌梗死的相关性.方法 对阜外心血管病医院2013年l至12月收治入院的1 988例急性心肌梗死（AMI）患者以及l 856例非冠心病患者的ABO血型等临床资料进行回顾性分析.采用Pearson卡方检验及logistic多元回归分析模型进行统计分析.P＜0.05为差异有统计学意义.结果 AMI组中A血型539例（27.1％）,B血型684例（34.4％）,AB血型215例（10.8％）,O血型551例（27.7％）.对照组中A血型496例（26.7％）,B血型598例（32.2％）,AB血型200例（10.8％）,O血型564例（30.4％）,AMI组与对照组的ABO血型分布差异无统计学意义.血型按O型与非O型分组,对照组中O型的比例略高于AMI组,但差异无统计学意义（P=0.06）.经logistic多元回归分析,在调整年龄、性别、高血压病、糖尿病、胆固醇水平和吸烟等心肌梗死危险因素后,A血型者（OR=1.229,95％ CI：1.019～1.482,P=0.031）和B血型者（OR=1.214,95％ CI：1.017～1.449,P=0.032）罹患AMI的风险显著高于O血型者;非O血型者罹患AMI的风险显著高于O血型者（OR=1.223,95％ CI：1.048～1.426,P=0.01）.结论 提示非O血型与AMI存在着独立相关性,非O血型可能增加AMI的发生风险.

Objective To explore the association between the ABO blood group and the risk of myocardial infarction in Chinese people.Methods We retrospectively recruited 1 988 consecutive patients with acute myocardial infarction （AMI） and 1 856 non-coronary artery disease （non-CAD） subjects who hospitalized in our hospital between January 2013 and December 2013.The clinical features and ABO blood group were analyzed.Results Blood group distribution was A （27.1%,539/1 988）,B （34.4%,684/1 988）,AB（10.8%,215/1 988）,O （27.7%,551/1 988） in patients with AMI and A （26.7%,496/1 856）,B（32.2%,598/1 856）,AB （10.8%,200/1 856）,O （30.4%,564/1 856） in non-CAD group.The single factor analysis showed that blood group O tended to be more common in the non-CAD group than in AMI group （P =0.06）.After adjustment for common cardiovascular risk factors such as age,gender,hypertension,diabetes,smoking and serum cholesterol level,the A,B,and AB blood groups were associated with increased risk of AMI compared with O blood group,and the difference was significant with A blood group （OR =1.229,95% CI 1.019-1.482,P =0.031） and B blood groups （OR =1.214,95% CI 1.017-1.449,P =0.032）.In addition,non-O blood group remained significantly associated with the increased risk of AMI than O blood group after logistic regression analysis（OR =1.223,95% CI 1.048-1.426,P =0.01）.Conclusion Our results suggest that non-O blood group is associated with the increased risk of AMI.