孟鲁司特联合布地奈德治疗儿童哮喘有效性和安全性的Meta分析

Meta Analysis Of the Efficacity and Security of Montelukast Combining with Budesonide Curing Asthma in Children

目的探讨孟鲁司特联合布地奈德治疗儿童哮喘的有效性和安全性。方法检索2005—2014年的中国期刊全文数据库、中文期刊全文数据、万方数据知识服务平台,通过对Jadad量表质量评价检索到的10篇文献进行筛选后,根据Cochrane协助网提供的软件Review Manager 5.2进行Meta分析。结果共检索到74篇文献,按照纳入和排除标准,最后筛选10篇,对767例哮喘患儿进行Meta分析。总有效率(P=0.98,I2=0%)来源的文献具有同质性,差异有统计学意义(Z=5.48,P<0.00001);FEV1和PEF有异质性;不良反应具有同质性。结论孟鲁司特联合布地奈德治疗儿童哮喘的临床疗效明显,有效性较高;但不良反应差异无统计学意义。

Objective To adesonide curing asthma in children.Methods Search of China journal full text database, VIP Chinese Journal Resources Integration Service Platform（V6.5）,Wanfang Data knowledge service platform in 2005—2014;Jadad was used to evaluate the quality of the 10 documents retrieved,Meta analysis uses Review Manager 5.2,the Software provided by the Cochrane Collaboration.Results A total of 74 articles were retrieved,and 10 were selected According to the inclusion and exclusion criteria,and 767 children with asthma were analyzed by Meta.The total effective rate（P=0.98,I^2=0%）of the source of the literature is homogeneous,the difference was statistically significant（Z=5.48,P〈0.00001）;PEF and FEV1 were heterogeneous;adverse reactions were homogeneous. Conclusion Clinical curative effect of montelukast combining with budesonide curing asthma in children is Obvious.But there was no significant difference in adverse reactions.