经皮给药辅助治疗小儿支气管哮喘的临床疗效

Effect of Transdermal Drug Delivery in the Treatment of Bronchial Asthma in Children

目的探讨经皮给药辅助治疗小儿支气管哮喘的临床疗效。方法选取2013年6月至2014年6月本溪市铁路医院收治的支气管哮喘患儿资料100例,按随机数字表法将其分为观察组和对照组,各50例。对照组患儿采用沙丁胺醇喷雾剂及布地奈德喷雾剂治疗,观察组患儿在对照组基础上联合妥洛特罗贴剂经皮给药治疗,比较两组患儿的临床疗效。结果观察组患儿喘憋、喘鸣音及咳嗽消失时间均明显短于对照组,差异均有统计学意义(均P<0.05);观察组患儿总有效率为94.0%,明显高于对照组的76.0%,差异有统计学意义(P<0.05)。结论经皮给药辅助治疗小儿支气管哮喘临床效果明显,起效快,且安全性高。

Objective To investigate the clinical effect of transdermal medicine auxiliary treatment of bronchial asthma in children.Methods From June 2013 to June 2014,100 patients with bronchial asthma were randomly divided into observation group and control group by random number table method,50 cases in each group.In control group were treated with salbutamol aerosol sprays and budesonide spray treatment and observation groups of children in the control group based on the combined tulobuterol patch percutaneous give drug treatment,The clinical effect of two groups of children were compared.Results Observation group of children with wheezing,wheezing and cough disappeared time were significantly shorter than that of the control group,differences were statistically significant（P〈0.05）;clinical observation group with total efficiency was 94.0%,which was significantly higher than that of the control group 76.0%,the difference is statistically significant（P〈0.05）.Conclusion The clinical effect of the treatment of children with bronchial asthma is obvious,and the safety is high.