老年2型糖尿病患者骨矿密度研究

The research on the bone mineral density of elderly patients with type 2 diabetes

目的应用双能X线骨密度仪,探讨老年2型糖尿病患者骨矿密度(BMD)的变化情况。方法以国际临床骨测量学会制定的骨密度测定方法学为标准,分别测量118例老年2型糖尿病患者和97例老年健康志愿者(对照组)的骨密度,测量部位包括腰椎、股骨近端和非优势侧前臂骨1/3段,比较两组BMD变化。结果老年2型糖尿病患者腰椎、左侧股骨近端和左侧前臂骨1/3段BMD绝对值分别为:(0.79±0.21)g/cm^2,(0.78±0.19)g/cm^2,(0.65±0.18)g/cm^2,低于健康对照组(0.99±0.17)g/cm^2,(0.91±0.14)g/cm^2,(0.89±0.16)g/cm^2,两组差异有统计学意义(t=-6.53,-4.12,-5.37;P<0.01)。老年2型糖尿病组男性腰椎[(0.78±0.20)g/cm^2]、股骨近端[(0.74±0.23)g/cm^2]、左侧前臂骨1/3段[(0.66±0.18)g/cm^2]BMD值均大于女性[(0.74±0.23)g/cm^2]、股骨近端[(0.69±0.15)g/cm^2]、左侧前臂骨1/3段[(0.65±0.15)g/cm^2],差异有统计学意义(t=-5.62,-5.49,-4.37;P<0.01)。健康对照组男性腰椎[(1.06±0.14)g/cm^2]、股骨近端[(0.94±0.11)g/cm^2]、左侧前臂骨1/3段[(0.95±0.14)g/cm^2]BMD值均大于女性[(0.98±0.13)g/cm^2]、股骨近端[(0.93±0.14)g/cm^2]、左侧前臂骨1/3段[(0.91±0.13)g/cm^2],差异有统计学意义(t=-6.19,-7.38,-3.49;P<0.01)。结论各年龄段老年2型糖尿病患者腰椎、股骨近端和前臂骨BMD均低于同年龄段健康人群;男性BMD值均大于女性。

Objective To study the bone mineral density （BMD） changes of elderly patients with type 2 diabetes by dual energy x-ray absorptiometry （DXA） machine.Methods Taking the methodological standards of BMD measurement of International Society for Clinical Densitometrt （ISCD） as criteria, one hundred and eighteen elderly patients with type 2 diabetes and ninety-seven elderly healthy volunteers were recruited in the study and underwent BMI） measurement ,respectively.Lumbar spine, proximal femur and 1/3 of non-dominant side forearm bone were selected.Then quantitative analysis was made to compare differences of the BMD in the two groups of subjects. Results The BMD absolute value of lumbar spine, proximal femur and 1/3 of non-dominant side forearm bone in type 2 diabetes were （0.79±0.21）g/cm2, （0.78±0.19）g/cmz and （ 0.65 ±0.18） g/cm2, respectively, which were significantly lower than those of the healthy control group （0.99±0.17） g/cm2, （0.91 ±0.14） g/cm2 and （0.89±0.16） g/cmz, （ t =-6.53,-4.12,-5.37; all P 〈0.01 ）. The BMD of lumbar spine, proximal femur and 1/3 of non-dominant side forearm bone in elderly male patients with type 2 diabetes were [ （ 0.78± 0.20 ） g/cm2, （ 0.74±0.23 ） g/cm2, （ 0.66± 0.18 ） g/cm2 ], which were significantly higher than those in female patients [ （0.73±0.23） g/cm2, （0.69±0.15） g/cm2, （0.65± 0.15 ） g/era2 ] , （ t = -5.62, -5.49, -4.37 ; all P 〈0.01 ） .The BMD of lumbar spine, proximal femur and 1/3 of non-dominant side forearm bone in healthy men were [ （ 1.06±0,14） g/cm2, （ 0.94±0.11 ） g/cm2, （ 0.95± 0.14）g/cm2], which were significantly higher than those in female [ （ 0.98 ± 0.13）g/em2, （ 0.93 ±0.14）g/cm2,（0.91±0.13）g/cm2],（ t =-6.19,-7.38,-3.49;allP〈0.01）.Condusion The BMD of lumbar spine, proximal femur and forearm bone of elderly patients in all ages with type 2 diabetes are lower than those of elderly healthy people.