清化痰瘀方联合易善复治疗非酒精性脂肪性肝炎的疗效观察

The Clinical Observation of Qinghuatangyu Decoction Combined with Essentialeon the Rehabilitation Treatment of Nonalcoholic Fatty Liver Disease

目的观察清化痰瘀方治疗非酒精性脂肪性肝炎的临床疗效。方法将60例患者随机分为2组,治疗组30例给予清化痰瘀方合多烯磷脂酰胆碱胶囊(易善复)治疗,对照组30例给予易善复治疗,2组疗程为6个月。观察2组患者治疗前后症状的改善情况、肝功能、血脂以及肝/脾CT比值。2组患者在用药治疗期间均适当加强体育锻炼及控制饮食。结果治疗组总有效率为86.7%,对照组总有效率为73.3%,治疗组优于对照组(P<0.05)。2组治疗6个月后ALT、AST、GGT、TC、HDL-C、UA、TNF、肝/脾CT比值的变化,治疗组优于对照组(P<0.05)。结论清化痰瘀方治疗非酒精性脂肪性肝炎具有良好的临床疗效,可明显改善患者中医症候、肝功能、血脂、血清尿酸、肿瘤坏死因子、肝/脾CT比值。

Objective To observe the clinical curative effect of Qinghuatangyu decoction on the rehabilitation treatment of nonalcoholic fatty liver disease. Methods 60 cases of patients were randomly divided into the treatment group and the control group on average,the treatment group given 6 months＇ treatment of Qinghuatangyu decoction combined with polyene phosphatidylcholine capsules（Essentiale）,the control group was given only 6 months＇ treatment of Essentiale. Observe both of two groups＇ improvements of the symptoms,the liver function,blood lipid and liver/spleen CT ratio in pretherapy and post-treatment. The patients of two groups were suitable to enhance physical exercise and control diet during treatment. Results The total effective rates of treatment group and control group were 86. 7% and 73. 3% respectively,the treatment group is better than that of control group（P〈0.05）. After treatment for 6 months,the changes of treatment group＇s ALT,AST,GGT、TC、HDL-C、UA、TNF,liver/spleen CT ratio are better than that of control group（P〈0.05）. Conclusion There is a better clinical curative effect of Qinghuatangyu decoction on the rehabilitation treatment of nonalcoholic fatty liver disease,which can significantly improve the patients＇ TCM symptoms,liver function,blood fat,serum uric acid,tumor necrosis factor and liver/spleen CT ratio.