肿瘤治疗的新标靶——谷氨酰胺依赖

A new Target for Cancer Therapy- Glutamine Addiction

谷氨酰胺(Glutamine,Gln)是体内最丰富的氨基酸,也是氨循环最主要的无毒载体,它是很多细胞生长所必需的,特别是对于快速生长的肿瘤细胞,Gln是其能量供应的主要来源。本文对肿瘤细胞中Gln代谢及其调控信号通路研究进展作一概述,并探讨了利用Gln依赖这一特征作为某些肿瘤靶向治疗的可能性。

Glutamine （ Glutamine,Gln） is the most abundant amino acid in vivo ,and also the main non-toxic carrier of ammonia of Ammonia cycle ,which is necessary for the growth of many cells.As for the rapid growth of tumor cells,Gln is the main energy supply sources.This paper addresses the progress on the metabolism of glutamine in cancer cell,the signaling pathways that regulate the cellular utilization of glutamine ,and potential therapeutic strategies that might exploit the dependence of certain cancer cells on glutamine.