布地奈德联合华法林钠治疗结肠炎的疗效观察

Clinical Observation of Budesonide Combined with Warfarin on the Treatment of Colitis

目的针对结肠炎患者采用华法林钠与布地奈德联合的方法进行治疗,并探究分析其治疗的临床效果。方法将自2014年4月至2015年4月在本院接受治疗的112例结肠炎患者根据根据随机投掷的方法分成对照组与观察组,每组56例,对照组仅服用布地奈德,观察组加用华法林钠进行治疗,对比两组患者用药后的不良反应情况与临床总有效率。结果经过用药1个疗程后,观察组的总有效率(94.64%)明显高于对照组的(69.64%),其差异据有统计学意义(P<0.05);用药后观察组不良反应发生率(3.57%)与对照组的(8.93%)无明显差异(P>0.05)。结论针对结肠炎患者采用华法林钠与布地奈德联合的方法进行治疗的临床效果相对于仅服用布地奈德在一定程度具有明显的优势,建议广泛使用。

OBJECTIVE To explore and analyze the clinical effect of budesonide combined with warfarin on the treatment of colitis.METHODS 112 cases of colitis patients who achieved treatment in our hospital from 2014 April to 2015 April were divided into control group and observation group by random throwing method ,with 56 cases in each group , control group was received budesonide , observation group was treated with warfarin.Adverse reactions and effect after treatment of two groups were compared.RESULTS After a course of treatment ,the total effective rate in observation group （94.64%） was significantly higher than that of the control group （69.64%） （ P〈0.05 ）;Drug adverse reaction rate of the observation group （3.57%） and control group （8.93%） had no significant difference （ P〉0.05 ）.CONCLUSION The effect of warfarin combined with budesonide on the treatment of colitis patients has obvious advantages in a certain extent compared with using budesonide only ,which is worthy of promotion in clinic.