CT指导慢性阻塞性肺疾病急性加重期抗菌药应用价值分析

Application of CT in guidance of antibiotics use for AECOPD patients

目的探讨CT指导慢性阻塞性肺疾病急性加重期抗菌药应用临床价值,为抗菌策略的制定提供参考。方法选取我院收治的慢阻肺急性加重期患者108例,随机分为对照组和观察组,分别依据Anthonisen分型和CT水平变化指导抗菌药物应用,比较两组患者临床疗效。结果观察组抗菌药物使用比例、使用天数及住院天数均显著优于对照组(P<0.05);观察组出院到再次急性发作间隔时间和出院后1年内因慢阻肺急性发作再次住院次数均显著优于对照组(P<0.05)。结论 CT水平用于慢阻肺急性加重期抗菌药物应用指导可显著降低抗菌药物用量,缩短病程及降低复发风险。

Objective To investigate the application value of CT in guidance antibiotics use for AECOPD patients. Methods 108 patients with AECOPD were randomly divided into the observation group and the control group, which were given antibiotics according to Anthonisen type and CT changes respectively. The clinical effect was compared. Results The proportion of antimicrobial agent use and time and the duration of hospital stay were betterin the observation group than in the control group （ P〈0. 05 ） . The incidence of acute attack 1 year after discharge was lower in the observation group than in the control group （P〈0. 05）. Conclusion CT changes can guide the use of antibiotics, shorten the course of disease and reduce the risk of recurrence.