雾化吸入3%氯化钠溶液治疗脑性瘫痪婴儿毛细支气管炎疗效观察

Clinical observation of 3% hypertonic saline aerosol inhalation in the treatment of bronchiolitis in infants with cerebral palsy

目的探讨3%氯化钠溶液雾化吸入治疗脑性瘫痪(简称脑瘫)婴儿毛细支气管炎(BC)的疗效,为临床治疗经济条件较差的脑瘫患儿的BC提供依据。方法将75例脑瘫合并BC的婴儿随机分为两组:观察组35例,雾化吸入3%氯化钠溶液4 ml,对照组40例,雾化吸入"布地奈德2 ml+异丙托溴铵1.25ml",均为每8 h 1次。比较两组患儿肺部哮鸣音消失时间、湿啰音消失时间、临床疗效和不良反应。结果观察组和对照组相比,肺部哮鸣音消失时间和湿啰音消失时间之间的差异均无统计学意义(P>0.05);临床疗效,观察组91.43%,对照组95.00%,两组相比差异无统计学意义(P>0.05);不良反应,观察组为0,对照组5例(12.5%),两组相比差异有统计学意义(P<0.05)。结论 3%氯化钠溶液雾化吸入治疗BC,疗效好、无副作用、费用低,特别适合治疗经济条件较差的脑瘫患儿的BC。

Objective To observe the clinical effect of aerosol inhalation of 3% hypertonic saline on bron-chiolitis （ BC） in infants with cerebral palsy （ CP） . Methods 75 cerebral palsy infants with bronchiolitis were ran-domly divided into two groups. The observation group was given the inhalation of 4 ml 3% hypertonic saline （ n=35）, and the control group was given the inhalation of 2 ml budesonide and 1. 25 ml isopropyl bromide （n=40）. Both groups were given once per 8 hours （q8h）. The disappearance time of lung signs, clinical efficacy and adverse reactions were compared between the two groups. Results The disappearance time of lung signs and clinical efficacy showed no significant difference between the observation group （ 91. 43%） and the control group （ 95. 00%） （ P〉0. 05）, while the adverse reaction in observation group （0 case） was significantly lower than that in the control group （5 cases） （P〈0. 05）. Conclusion 3% hypertonic saline aerosol inhalation is effective, safe and economic in the treatment of bronchiolitis in infants with cerebral palsy.