河北省任丘地区老年人高尿酸血症与血脂相关性的研究

Analysis of correlation between hyperuricemia and blood lipids of the elderly in Hebei Renqiu

目的：探讨任丘地区城乡60～70岁老年人高尿酸血症（HUA）与血脂的相关性，为指导该地区老年人疾病防治提供依据。方法采用整群随机抽样法，以任丘市城乡年龄60～70岁的常住居民为筛查对象，共计5010名，其中男性2163名（43．2％），女性2847名（56．8％），平均年龄（64．29＆#177;3．05）岁，进行血尿酸（UA）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-L）、低密度脂蛋白胆固醇（LDL-L）检测。分析 UA 与性别、血脂之间的相关性。采用 Logistic 回归方法对 HUA 与血脂各组分之间的关系进行分析。结果任丘地区老年人 HUA 的患病率为6．1％，其中老年男性 HUA 的患病率为9．8％，老年女性 HUA 的患病率为3．2％。男性 HUA 组中尿酸、TG、LDL-L 水平分别为464．10（438．00～508．65）μmol／L、1．54（1．00～2.19）mmol／L、2．66（2．25～3．22）mmol／L，高于尿酸正常组的294．00（249．90～338．08）μmol／L、1．13（0．84～1．65）mmol／L、2．57（2．12～3．01）mmol／L（均 P ＜0．05）；女性 HUA 组中尿酸、TG、LDL-L 水平分别为454．15（434．15～480．78）μmol／L、2．14（1．47～3．18）mmol／L、2．96（2．52～3．76）mmol／L，高于尿酸正常组的250．80（209．00～299．80）μmol／L、1．53（1．10～2．20）mmol／L、2．87（2．40～3．33）mmol／L（均 P ＜0．05）。多因素Logistic 回归分析显示，TG 是 HUA 的独立危险因素，HDL-L、性别为 HUA 的保护因素。结论HUA 与血脂密切相关，以 TG、HDL-L 为著，根据血脂异常情况进行 HUA 筛查并干预，可减少心脑血管等疾病的发生。

Objective To investigate the hyperuricemia（HUA）and the correlation of blood lipids of the 60 -70years peple in Renqiu area,and to provide the basis for guiding prevention and treatment of the elderly disease the region.Methods According to the cluster random sampling method,Renqiu permanent residents with the age of 60 to 70 years were selected as a screening object.In the total 5 010 cases screened object,2 163 were male（43.2%）,2 847 were female（56.8%）,with an average age of（64.29 ＆#177;3.05）years.The data of blood uric acid and total cholesterol（TC）, triglyceride（TG）,high -density lipoprotein（HDL -C）,low -density lipoprotein（LDL -C）were collected.The rela-tionship between blood uric acid and blood lipids were analyzed.Logistic regression method was used to analysis the relationship between the hyperuricemia and lipids components.Results The overall prevalence of hyperuricemia in Renqiu was 6.1%（9.8% in male,3.2% in female）.In men HUA group,the levels of blood uric acid,TG and LDL-L were 464.10（438.00 -508.65）μmol/L,1.54（1.00 -2.19）mmol/Land 2.66（2.25 -3.22）mmol/L,which were higher than those of normal uric acid group of 294.00（249.90 -338.08）μmol/L,1.13（0.84 -1.65）mmol/L and 2.57（2.12 -3.01）mmol/L（P 〈0.05）.In women HUA group,the levels of blood uric acid,TG and LDL -L were 454.15（434.15 -480.78）μmol/L,2.14（1.47 -3.18）mmol/L and 2.96（2.52 -3.76）mmol/L,which were higher than those of normal uric acid group of 250.80（209.00 -299.80）μmol/L,1.53（1.10 -2.20）mmol/L and 2.87（2.40 -3.33）mmol/L（P 〈0.05）.Logistic multi -factor regression analysis showed that TG was an independ-ent risk factor for hyperuricemia,and that HDL -L and gender were protective factors.Conclusion Hyperuricemia is closely associated with blood lipid,especially with TG and HDL -L,so we could screening HUA by blood lipid,which can reduce the occurrence of cardiovascular disease effectively.