血清降钙素原、白细胞介素6在腰椎间盘突出症患者早期诊断与预后评估中的意义

A study on the role of procalcitonin （PCT）and interleukin -6 （IL -6）in the early diagnosis and prognostic evaluation of the patients with lumbar intervertebral disc herniation

目的：探讨血清降钙素原（PCT）、白细胞介素6（IL-6）在腰椎间盘突出症患者早期诊断与预后评估中的价值，及其与病程、腰椎功能的相关性。方法收集腰椎间盘突出症患者100例（观察组）及非腰椎源性疾病患者35例（对照组），对术前临床症状均给予日本骨科学会腰椎功能评分（JOA 评分），应用酶联免疫吸附法测定两组患者 PCT 和 IL-6的含量变化，通过直线相关分析探讨 PCT、IL-6与病程等的相关性。结果观察组血清 PCT、IL-6含量分别为（22．76±1．73）ng／L、（215．34±2．37）ng／L，对照组血清 PCT、IL-6含量分别为（9．75±2．36）ng／L、（51．22±2．65）ng／L，两组差异均有统计学意义（t ＝44．46、463．37，均 P ＜0．001）；IL-6与腰椎间盘突出症患者病程长短呈正相关（r ＝0．32，P ＝0．000），与患者 JOA 评分呈负相关（r ＝－0．45，P ＝0．003），PCT 与患者病程长短呈正相关（r ＝0．35，P ＝0．001），与患者 JOA 评分呈负相关（r ＝－0．53，P ＝0.005）。结论PCT、IL-6在腰椎间盘突出症早期诊断中有一定的作用，且与患者病程、腰椎功能情况变化有一定的相关性。

Objective To explore the value of procalcitonin （PCT）and interleukin -6 （IL -6）in the early diagnosis and prognostic evaluation of the patients with lumbar intervertebral disc herniation,and their correlation with the course and lumbar function.Methods 100 patients with lumbar disc herniation （study group）and 35 patients with lumbar non -borne diseases （control group）were collected,their preoperative clinical symptoms were scored on the basis of the lumbar scoring system of Japanese Orthopaedic Association （JOA）,the enzyme -linked immunosor-bent assay was applied to determining the content changes of PCT and IL -6 of the two groups,and the linear correla-tion analysis was used to explore the relevance of PCT and IL -6 to the course.Results The contents of the PCT and IL -6 in the study group＇s serum were respectively （25.13 ±0.86）ng/L and （10.26 ±0.36）ng/L,while those in the control group＇s serum were respectively （223.85 ±0.61）ng/L and （50.11 ±1.23）ng/L,both with statistical sig-nificance （t =2.542,2.206,P 〈0.01）.The IL -6 was positively correlated with the disease duration of the patients with lumbar disc herniation （r =0.32,P =0.000）,and negatively correlated with their JOA score （r =-0.45,P =0.003）,and the PCT was positively correlated with the patients＇disease duration （r =0.35,P =0.001）,and nega-tively correlated with their JOA score （r =-0.53,P =0.005）.Conclusion The PCT and IL -6 have a certain role in the early diagnosis of lumbar disc herniation,and have some relevance to the course of disease and the lumbar func-tion changes.