磷酸肌酸钠联合丹参多酚酸盐治疗冠心病心力衰竭疗效观察

The effect of creatine phosphate combined with salvia miltiorrhiza polyphenols acid salt in treatment of coro-nary heart disease with heart failure

目的：观察磷酸肌酸联合丹参多酚酸盐治疗冠心病心力衰竭的临床疗效。方法114例冠心病心力衰竭患者为研究对象，采用随机数字表法分为对照组55例和研究组59例；两组均给予抗心力衰竭常规治疗，研究组在此基础上，给予磷酸肌酸钠联合丹参多酚酸盐；观察并比较两组患者的临床疗效。结果研究组总有效率为96．61％（57／59），明显高于对照组的85.45％（47／55），差异有统计学意义（χ^2＝4.427，P ＝0．035）。治疗前，两组左心射血分数（LVEF）﹑左室舒张末内径（LVEDD）﹑左室收缩末内径（LVESD）和6 min 步行距离差异均无统计学意义（均 P ＞0．05）；治疗后，研究组 LVEDD 和 LVESD 值均下降，LVEF 和6 min 步行距离均升高，差异有统计学意义（P ＜0．05），研究组 LEVSD、LVEDD 低于对照组，LVEF 及6 min 步行距离高于对照组，差异均有统计学意义（均 P ＜0．05）；两组均未发现与治疗相关的并发症或副作用。结论磷酸肌酸钠联合丹参多酚酸盐能够改善患者心功能各项指标，且副作用少。

Objective To explore the effect of creatine phosphate combined with salvia miltiorrhiza polyphe-nols acid salt in treatment of coronary heart disease heart failure.Methods 114 cases of patients with coronary heart disease heart failure were selected as research objectives,who were treated in our hospital from August 2012 to August 2014.And they were randomly divided into control group（55 cases）and research group（59 cases）according to the number table method.Routine therapy of heart failure were given in both groups and the research group were added creatine phosphate combined with salvia miltiorrhiza polyphenols acid salt.The clinical efficacy of two groups of patients were observed and compared.Results The total effective rate in research group was 96.61%（57 /59）, significantly higher than 85.45%（47 /55）in control group,the difference was statistically significant（χ^2 =4.427, P =0.035）.Before treatment,the left ventricular ejection fraction（LVEF）,left ventricular end diastolic diameter （LVEDD）,left ventricular end systolic diameter（LVESD）and 6min walking distance between two groups had no sig-nificant difference（P 〉0.05）.After treatment,the LVEDD and LVESD of research group were decreased and LVEF and 6 minutes walking distance of two groups were increased,the difference was statistically significant（P 〈0.05）, the LVEDD and LVESD of research group were lower than that of the control group and LVEF and 6 minutes walking distance were higher than that of control group,the difference was statistically significant（P 〈0.05）.No complications or side effects related to the treatment were found in both groups.Conclusion On the basis of routine therapy of heart failure,the effect of creatine phosphate sodium combined with salvia miltiorrhiza polyphenols acid salt in treat-ment of coronary heart disease heart failure can improve cardiac function of the patients with the indicators,and the clinical effect is obvious,and side effects is rarely observed.