肝衰竭并发侵袭性真菌病的诊治及预防

Management and prevention of invasive fungal disease in liver failure

肝衰竭的并发症临床上表现复杂多样,极易并发局部或全身的侵袭性真菌病(IFD),继发其他脏器的损伤,从而导致肝损伤的进一步加重,使其形成"恶性循环"的病理进程,最终导致多脏器功能衰竭,病死率极高,成为临床处理中的"棘手问题"。介绍了肝衰竭并发IFD的原因、症状、诊断、治疗、预后、预防等方面的研究进展,探讨了近年来关于肝衰竭并发IFD的一些共识和争议,阐述其研究的意义及前景,旨在提高肝衰竭并发IFD的临床诊断和治疗水平。

Liver failure is a clinical critical illness, and its complications have various clinical manifestations, often resulting in local or systemic invasive fungal disease （IFD）. The damage of other organs may occur secoudalT to IFD in liver failure patients, thus worsening liver injury. This will ultimately lead to multiple organ failure with extremely high fatality, so it is very difficult to manage. To investigate the causes, symptoms, diagnosis, treatment, prognosis, and prevention of IFD in liver failure, this article reviews the consensus and controversy over IFD in liver tailure in recent years and describes the significance amt prospect of its research, with the purpose of improving the clinical diagnosis and treatment of IFD in liver failure.