摘要1临床资料患者男性,66岁,因＂尿泡沫增多,双下肢水肿2个月余＂在当地医院就诊,按肾病综合征治疗18 d,病情未改善。于2014年2月12日以＂双下肢水肿近3个月＂收入本院。既往高血压病史20余年,饮酒史20余年,100 g/d。查体：体温37.0℃,心率57次/min,呼吸18次/min,血压130/90 mm Hg。心、肺检查未见异常。
5VRANA JA, GAMEZ JD, MADDEN B J, et al. Clasification of amyloidosis by laser micro dissection and mass spectrometry - based proteomic analysis in clinical biopsy specimens [ J ]. Blood, 2009, 114(24) : 4957 -4959.
7SCHONLAND SO, DREGER P, de WITTE T, et al. Current status of hematopoietic cell transplantation in the treatment of systemic amyloid light - chain amyloidosis[ J ]. Bone Mar- row Transplant, 2012, 47 ( 7 ) : 895 -905.
9WALL JS, KENNEL S J, STUCKEY AC, et al. Radioimmuno- detection of amyloid deposits in patients with AL amyloidosis [J]. Blood, 2010, 116 (13):2241 -2244.
2Gertz MA,Comenzo R,Falk RH,et al.Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL):a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis,Tours,France,18-22April 2004.Am J Hemato1,2005,79:319-328.
3Skinner M,Sanchorawala V,Seldin DC,et al.High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis:an 8-year study.Ann Intern Med,2004,140:85-93.
4Wechalekar AD,Gillmore JD,Lachmannl HJ,et al.Efficacy and safety of bortezomib in systemic AL amyloidosis --a preliminary report.Blood (ASH Annual Meeting Abstracts),2006,108:129.
5Kastritis E,Wechalekar AD,Dimopoulos MA,et al.Significant activity of bortezomib-based therapy in patients with primary systemic (AL) amyloidosis.Blood (ASH Annual Meeting Abstracts),2008,112:869.
6Wechalekar AD,Lachmann HJ,Offer M,et al.Efficacy of bortezomib in systemic AL amyloidosis with relapsed/refractory clonal disease.Haematologica,2008,93:295-298.
7Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med,2003,349(6) :583 -596.
8Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol, 1995,32 ( 1 ) : 45 -59.
9Rajkumar SV, Gertz MA. Advances in the treatment of amyloidosis. N Engl J Med,2007,356(23) :2413 -2415.
10Cohen AD, Comenzo RL. Systemic light-chain amyloidosis: advances in diagnosis, prognosis, and therapy. Hematology Am Soc Hematol Educ Program,2010,2010:287 - 294.
