摘要
肾素-血管紧张素系统(RAS)是一种经典的循环酶通路,在胰腺功能活动调解中起着重要作用。近几年来随着人们对RAS的认识不断加深,发现RAS轴不仅包括经典轴ACE-AngⅡ-AT1轴,还包括新轴ACE2-Ang(1-7)-Mas轴。已有多项研究证实,ACE2-Ang(1-7)-Mas轴能对抗RAS经典轴的作用。综述了胰腺局部RAS两条轴各自的组成、功能及两者的比较分析。
The renin - angiotensin system （RAS） is a classical circulating enzyme pathway that plays an important role in regulation of pan- creatic function. In recent years, with deepening understanding of RAS, researchers found that RAS not only includes the classical ACE - Ang II - AT1 axis, but also includes the new ACE2 - Ang （ 1 - 7 ） - Mas axis. Extensive studies have confirmed that the ACE2 - Ang （ 1 - 7 ） - Mas axis can antagonize the effect of the ACE - Ang II - AT1 axis. This paper reviews the composition and function of both axes of the RAS in the local pancreas, and also presents the comparison between the two axes.
出处
《临床肝胆病杂志》
CAS
2015年第9期1554-1557,共4页
Journal of Clinical Hepatology
基金
北京市自然科学基金资助项目(7142044)
