rs10795668单核苷酸多态性与中国北方汉族结直肠癌易感性的关系

Relationship of the polymorphism of rs10795668 single nucleotide and the susceptibility of colorectal cancer in north China Han population

目的探讨rs10795668单核苷酸多态性与北方汉族人群结直肠癌遗传易感性的关系。方法采用聚合酶链反应-限制性片断长度多态性方法,检测结直肠癌组182例（结肠癌113例,直肠癌69例）和对照组192例的rs10795668单核苷酸多态性基因型。采用非条件logistic回归分析进行基因-疾病关联分析与基因-性别交互作用分析。结果rs10795668多态性位点在结直肠癌患者中的基因型分布与在正常健康对照人群中的基因型分布差异无统计学意义,但基因型与性别在结肠癌中存在交互作用,AA＋AG基因型增加女性结肠癌的发生危险（OR=3.05,95%CI 1.47~6.35;P=0.00078）。结论 rs10795668单核苷酸多态性的AA＋AG基因型与中国北方汉族女性结肠癌遗传易感性有关,与直肠癌无关。

Objective To evaluate the relationship between the rs10795668 single nucleotide polymorphism （SNP） and the colorectal cancer （CRC） in north China Han population. Methods The genotype of rs10795668 SNP was detected by PCK- RFLP analysis in 113 colon cancer patients, 69 rectal cancer patients, and 192 age and sex matched controls. Unconditional logistic regression were used to comparatively analyze the genotype between patients and the controls adjusted by age and sex. Results No significant difference of rs 10795668 SNP was detected between colorectal cancer patients and normal controls, but it was found that an existence of interaction of gene and sex in colorectal cancer, and women with AA＋AG genotype may have lower risk of colon cancer （OR 3.05, 95% CI 1.47-6.35; P=0.00078）. Conclusion The AA＋AG genotype of rs10795668 SNP is associated with the genetic susceptibility of colon cancer, but not of rectal cancer, in north China Han women.