刺五加注射液对小鼠胃排空及小肠推进运动的影响

Effects of acanthopanax senticocous injection on gastric emptying function and intestinal propulsive function in mice

目的:观察刺五加注射液对小鼠胃排空及小肠推进运动的影响。方法:48只小鼠随机分为生理盐水组、阿托品组、乙酰胆碱组、刺五加组、(刺五加+阿托品)组、(刺五加+乙酰胆碱)组。给各组小鼠注射相应药物(0.2 m L/10g腹腔注射),采用美蓝排空法,观察刺五加注射液对小鼠胃排空与小肠推进的影响。结果:(刺五加+阿托品)组小鼠的胃残留率明显低于阿托品组(P<0.01),而(刺五加+乙酰胆碱)组明显高于乙酰胆碱组(P<0.01);(刺五加+阿托品)组的小肠推进率明显高于阿托品组(P<0.01),(刺五加+乙酰胆碱)组明显低于乙酰胆碱组(P<0.01)。结论:刺五加注射液对小鼠胃排空及小肠推进运动有双向调节作用。

Objective： To observe effects of acanthopanax senticocous injection on gastric emptying function and intestinal propulsive in mice.Methods： Mice were randomly divided into six groups： normal saline（ NS） group,Atropine（ Atr） group,Acetylcholine（ ACh） group,Acanthopanax senticoside saponins（ ASS） group,ASS ＋ Atr group,and ASS ＋ ACh group. All the mice were administered with the drugs（ 0. 2ml /10 g,ip.）,and methylene blue emptying method was used. The effects of ASS on gastric emptying function and intestinal propulsive function in mice were observed. Results： Compared with Atr group,the gastric residual rate of mice in ASS ＋ Atr group significantly decreased（ P〈 0. 01）. However,the gastric residual rate of ASS ＋ Ach group was significantly higher than that in ACh group（ P〈 0. 01）. Compared with the Atr group,the small intestinal propulsion ratio in the ASS ＋ Atr group was significantly higher（ P〈 0. 01）,with the ratio of the ASS ＋ Ach group significantly lower than that in the ACh group（ P〈 0. 01）. Conclusion： Acanthopanax senticocous injection has the bi- directional regulation effect on gastrointestinal movement of mice.