和田地区哈萨克族人群23个STR基因座遗传多态性

Genetic Polymorphism of 23 STR Loci of Kazak Population in Hotan Area

调查新疆和田地区哈萨克族人群23个STR基因座的遗传多态性。除D13S317基因座外,其他22个STR基因座的基因分布均符合Hardy-Weinberg平衡(P>0.05)。23个基因座的TDP达1-4.53×1029,CPE达0.999999 999 804。23个STR基因座在新疆和田地区的哈萨克族人群中有较高的多态性,所得的群体遗传学数据可为该地区的法医学个体识别、亲权鉴定提供基础数据。

The genetic polymorphism of 23 short tandem repeat （STR） loci of 1130 unrelated Kazak individuals in Hotan area of Xinjiang, was investigated with Goldeneye^TM24A PCR amplification Kit and the population genetics parameters were calculated with PowerStats statistic software. 22 loci were found no deviation from Hardy-Weinberg equilibrium （P 〉 0.05） except D 13S317 locus. Matching probability （PM） ranged from 0.0113 to 0.2035 together with the power of discrimination （DP） 0.7965 to 0.9887, polymorphism information content （PIC） 0.5688 to 0.9208, power of exclusion （PE） 0.3355 to 0.8408, heterozygosity （He） 0.6354 to 0.9221. The total discrimination power （TDP） and the combined power of exclusion （CPE） of 23 loci were 1-4.53×10^29 and 0.999 999 999 804, respectively. The 23 STR loci were highly polymorphic in Kazak population of Hotan area. The polymorphie information would serve as reference data for forensic personal identification and paternity testing.