血清胆红素、低密度脂蛋白与脑梗死发病及预后的关系

Research on serum bilirubin,low density lipoprotein cholesterol with the onset of cerebral infarction and prognosis

目的:探讨间接胆红素、低密度脂蛋白与脑梗死发病及预后之间的关系。方法:选取50岁以上的脑梗死急性期患者80例为病例组,同期本科室住院的50岁以上的非脑梗死患者60例为对照组。于入院时检测间接胆红素(Indirect bilirubin,IBIL)、低密度脂蛋白(Low density lipoprotein,LDL),并进行美国国立卫生研究院卒中量表(NIH Stroke Scale,NIHSS)评分,观察病例组与对照组之间上述指标的异同。结果:1.脑梗死组与对照组在性别、年龄、吸烟、糖尿病和高血压病史等基础资料方面比较,差异无显著性(P>0.05)。2.脑梗死组IBIL水平高于对照组,差异均具有显著性(P<0.05)。3.将入院时脑梗死患者分为NIHSS评分<7分和NIHSS评分≥7两组,两组IBIL、LDL水平比较,具有显著差异(P<0.05)。结论:脑梗死急性期IBIL水平增高;脑梗死急性期血清LDL、IBIL水平与脑梗死预后相关,其水平越高预后越差。

Objective：To investigate the relationship of pathogenesis and prognosis of cerebral infarction and indirect bilirubin,low density lipoprotein cholesterol.Methods：Eighty patients with acute cerebral infarction were collected as the case group and 60 cases of non-cerebral infarction as the control group,they are all over the age of 50.Indirect bilirubin（IBIL）,low density lipoprotein（LDL）were tested in these two groups respectively.The United States of NIHSS score were applied on the day of admission.The scores were compared between the two groups.Results：1.there was no significant difference in the cerebral infarction group and control group in gender,age,smoking,diabetes and high blood pressure and so on（P〉0.05）.2.IBIL level of cerebral infarction group is higher than the control group significantly（P〈0.05）.3In-patients with cerebral infarction were divided into NIHSS score〈7points and NIHSS score of 7or higher groups.The IBIL,LDL in two groups were significant difference（P〈0.05）.Conclusions：1.In the acute phase of cerebral infarction,the level of IBIL is increased.2.IBIL and LDL levels in the acute phase of cerebral infarction were associated with its prognosis,the higher the levels of these factors the worse the prognosis.