苦杏仁苷对老年糜烂性胃炎患者血清SOD、MDA和NO浓度的影响

Effects of amygdalin on serum SOD,MDA and NO levels in elderly patients with erosive gastritis

目的探讨苦杏仁苷对老年糜烂性胃炎患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)浓度的影响。方法选取老年糜烂性胃炎患者120例,随机分为对照组和实验组,每组60例,其中对照组给予奥美拉唑和胶体果胶铋常规治疗,实验组在对照组的基础上,给予口服苦杏仁苷0.5g,1次/日。比较两组患者的临床疗效,内镜下糜烂愈合程度,血清SOD、MDA及NO浓度变化。结果治疗后,实验组疗效明显优于对照组(P<0.05);实验组内镜下愈合程度明显优于对照组(P<0.05);实验组SOD浓度高于对照组,MDA、NO浓度低于对照组,差异有统计学意义(P<0.05)。结论苦杏仁苷能够改善老年糜烂性胃炎患者的临床疗效,加快糜烂的愈合,其作用机制可能与血清SOD、MDA和NO有关。

Objective To investigate the effect of amygdalin on serum SOD ,MDA and NO levels in elderly e‐rosive gastritis patients .Methods 120 elderly patients with erosive gastritis were selected and randomly divided into the control group and the experimental group ,60 cases in each group .The control group was given the routine treat‐ment of omeprazole and colloidal bismuth pectin ,while on this basis the experimental group was given oral amygdalin 0 .5 g ,once daily .The clinical effects ,endoscopic erosion healing degree and changes of serum SOD ,MDA and NO levels were compared between the two groups .Results The clinical efficacy after treatment in the experimental group was significantly superior to that in the control group ,the difference was statistically significant（P〈 0 .05） ;the gastroscopic erosive healing level in the experimental group was significantly better than that in the control group ,the difference was statistically significant （P 〈 0 .05） ;serum SOD level after treatment in the experimental group was higher than that in the control group ,while serum MDA and NO levels were lower than those in the control group , the differences were statistically significant （P 〈 0 .05） .Conclusion Amygdalin can improve the clinical efficacy in elderly patients with erosive gastritis and accelerates the erosion healing ,its mechanism may be related with serum SOD ,MDA and NO .