急性脑梗死患者凝血功能指标和D-二聚体变化研究

Study of coagulation function indicators and DD change in patients with acute cerebral infarction

目的探讨并发症及脑梗死面积对急性脑梗死(ACI)患者凝血功能指标及D-二聚体(DD)水平的影响。方法收集249例ACI患者,检测其凝血功能指标及血浆DD水平,按不同并发症或梗死面积分组进行统计学分析。结果不同并发症的ACI各组血浆DD、纤维蛋白原(Fib)水平显著高于健康对照组(P<0.05),凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)差异无统计学意义(P>0.05)。ACI合并高血压和冠心病患者纤维蛋白原降解产物(FDP)水平较健康对照组显著升高(P<0.05)。单纯ACI组Fib水平与ACI合并高血压和糖尿病患者差异有统计学意义(P<0.05),ACI合并高血压和冠心病组DD水平显著高于单纯ACI组(P<0.05)。大面积脑梗死患者Fib、DD及FDP水平显著高于小面积脑梗死患者(P<0.01)。结论 ACI患者血浆DD、Fib水平升高且与并发症及脑梗死面积有关。

Objective To investigate the influence of complications and cerebral infarction area on the coagula‐tion function indicators and D‐dimer（DD） level in the patient swith acute cerebral infarction（ACI） .Methods 249 ca‐ses of ACI were collected as the ACI group and detected plasma DD and coagulation function indicators .The detection data were analyzed statistically according to different complications or infarction areas .Results The levels of plasma DD and Fib in the ACI groups with different complications were significantly higher than those in the healthy control group（P〈 0 .05） ,while the differences of prothrombin time（PT ） ,activated partial thromboplastin time（APTT ） and thrombin time（TT ） showed no statistical significance between the two groups（P〉 0 .05） .In addition ,the fibrinogen degradation product（FDP） level in the ACI complicating hypertension and diabetes group was significantly increased compared with the healthy control group ;the Fib level had statistical difference between the simple ACI group and the ACI complicating hypertension and diabetes group（P〈 0 .05） ,the DD level in the ACI complicating hypertension and coronary heart disease group was significantly higher than that in the simple ACI group（P〈 0 .05） .The Fib ,DD and FDP levels in the massive cerebral infarction group were significantly higher than those in the small area cerebral infarction group（P〈 0 .01） .Conclusion The levels of plasma DD and Fib are increased in ACI patients and related with complications and cerebral infarction area .