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2型糖尿病患者体内6项指标的变化及其临床意义 被引量:5

Changes and clinical significance of 6 indicators in patients with type 2 diabetes mellitus
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摘要 目的探讨超敏C反应蛋白(hs-CRP),同型半胱氨酸(HCY),补体C3、C4,血脂水平[胆固醇(TC)、三酰甘油(TG)]变化在2型糖尿病(T2DM)及其并发症中的作用。方法选择T2DM患者112例,根据有无并发症,分为并发症组和单纯组,其中并发症组根据并发症分为大血管病变组、合并感染组、糖尿病肾病组、视网膜病变组和周围神经病变组5个亚组。同时选择健康体检人员52例作为健康对照组。测定各组hs-CRP、HCY、C3、C4、TC、TG的水平,对结果进行分析。结果与健康对照组比较,T2DM组hs-CRP、HCY、C3、C4、TC、TG均显著升高(P<0.05)。与单纯组比较,大血管病变组HCY、TC明显升高(P<0.05),合并感染组、糖尿病肾病组、视网膜病变组、周围神经病变组hs-CRP、HCY及TC明显升高(P<0.05)。并发症各亚组C3、C4水平均较单纯组显著降低(P<0.05)。合并感染组hs-CRP升高最明显,大血管病变组HCY升高最显著。结论对T2DM患者进行hsCRP、HCY、C3、C4、TC、TG的监测,有助于早期预防糖尿病并发症。 Objective To explore the role of hs‐CRP ,HCY ,C3 ,C4 and lipid levels(TC ,TG) in type 2 diabetes mellitus(T2DM ) and its complications .Methods 112 patients with T2DM were selected and divided into the compli‐cations group and simple group according to whether having complications .,in which the complications group were re‐divided into the 5 subgroups of macroangiopathy ,complicating infection ,diabetic nephropathy ,retinopathy and pe‐ripheral neuropathy .Contemporaneous 52 healthy individuals of physical examination were selected as the healthy control group .The hs‐CRP ,HCY ,C3 ,C4 ,TC and TG levels were detected in each group .The detection results were analyzed .Results The levels of hs‐CRP ,HCY ,C3 ,C4 ,TC and TG in the T2DM group were significantly increased compared with the healthy control group(P〈 0 .05) .The levels of HCY and TC in the macroangiopathy group were significantly increased compared with the simple group(P〈 0 .05) ,the levels of hs‐CRP ,HCY and TC in the compli‐cating infection ,diabetic nephropathy ,retinopathy and peripheral neuropath groups were significantly increased(P〈0 .05) .The levels of C3 and C4 in the diabetic complications subgroups were significantly decreased compared with the simple group(P〈 0 .05) .The increase of hs‐CRP level in the complicating infection group was most obvious and the increase of HCY level in the macroangiopathy group was most significant .Conclusion Monitoring hs‐CRP , HCY ,C3 ,C4 ,TC and TG in the patients with T2DM conduces to early prevent diabetic complications .
出处 《检验医学与临床》 CAS 2015年第19期2922-2923,2926,共3页 Laboratory Medicine and Clinic
关键词 2 型糖尿病 超敏 C 反应蛋白 同型半胱氨酸 补体 type 2 diabetes mellitus hs-CRP HCY complements
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