新疆维吾尔族与汉族患者幽门螺杆菌检出率分析

Analysis of Helicobacter pylori Detection Rate in Han and Uygur Patients in Xinjiang

目的探讨新疆地区不同消化系统疾病中维吾尔族与汉族患者幽门螺杆菌（Helicobacter pylori，Hp）检出率间的差异性。方法回顾性分析2012年1月～2014年3月于新疆维吾尔自治区人民医院消化科进行胃镜检查的1120例患者，据病理及电子胃镜检查结果分为：胃炎组、消化性溃疡组、胃癌组，分别纳入594例、264例、262例。采用^14C—UBT检测方法及胃黏膜活检组织病理学Hp检测，两项检测结果中，任一阳性或均为阳性者，判定为Hp感染阳性。结果研究对象中维吾尔族患者Hp检出阳性者在胃炎组、消化性溃疡组、胃癌组分别为102例（54．3％）、120例（88．2％）、68例（43．0％），汉族患者Hp检出阳性者在胃炎组、消化性溃疡组、胃癌组分别为140例（34．5％）、116例（90．6％）、46例（44．2％）。胃炎组内维吾尔族患者较汉族患者Hp检出率高，差异有统计学意义（x^2=20．808，P=0．000）；消化性溃疡组及胃癌组，组内维吾尔族患者与汉族患者检出率差异，均无统计学差异（P〉0．05）。结论新疆地区胃炎患者Hp检出率与民族因素具有相关性，胃癌及消化性溃疡患者Hp检出率与民族因素间未发现明确的相关性。

Objective To investigate Helicobacter pylori （Hp） detection rate in Han and Uygur patients with different gastrointestinal diseases in Xinjiang. Method From Jan. 2012 to Mar. 2014,1120 patients were recruited in this retrospective study in the Department of Gastroenterology of Xinjiang Uygur Autonomous Region People＇s Hospital. According to endoscopic and pathological,they were divided into three groups ： 594 cases in gastritis group, 264 cases in peptic ulcer group, 262 cases in gastric cancer group. Hp infection was diagnosed when Hp histopathological of gastric mucosal biopsy specimens or/and 14C - UBT test were positive. Results Hp detection rate in gastritis group, peptic ulcer group and gastric cancer group of Uygurs were found 102 cases（54.3% ）, 120 cases （88.2%） and 68 cases （43%）, respectively. That in gastritis group, peptic ulcer group and gastric cancer group of the Hans were found 140 cases （ 34. 5 % ） , 116 cases （90.6%） and 46 cases （44.2%） , respectively. Hp detection rate of gastritis group in the Uygurs was higher than in the Hans with significantly difference （X2 = 20. 808,P = 0. 000）. Hp detection rate had no significant difference （P 〉 0.05） between peptic ulcer group/gastric cancer group and ethnicity. Conclusion There was association between gastritis group of Hp detection rate and ethnicity. There was no obviously correlation between gastric cancer group/peptic ulcer group of Hp detection rate and ethnicity, in Xinjiang.