GSTT1基因与中国人群结直肠癌易感性的相关性Meta分析

Meta-analysis of the association between GSTT1 and the susceptibility to colorectal cancer among Chinese population

目的探讨GSTT1基因与中国人群结直肠癌易感性的关系。方法计算机检索PubMed、EMBase、CochraneLibrary、中国生物医学文献数据库、维普中文科技期刊全文数据库、中国期刊全文数据库和万方医药期刊全文数据库，全面检索GSTT1基因与中国人群结直肠癌易感性的临床对照研究。按纳入与排除标准筛选文献，对符合条件的研究由两位研究者独立进行资料提取和质量评价，采用RevMan5．1软件进行Meta分析。结果共检索出326篇文献，最终纳入10篇病例对照研究，其中结直肠癌患者2983例，对照组共纳入健康人4386例。Meta分析结果显示GSTT1基因是否缺失与结直肠癌易感性相关（RR=1．11，95％C，为1．06-1．17，Z=4．26，P〈0．0001）。结论在中国人群中GSTT1基因缺失增加了结直肠癌的患病风险。

Objective To assess the association between glutathione S-transferase T1 （GSTT1） gene and the susceptibility of colorectal cancer among Chinese population. Methods Clinical controlled trials of the association between GSTT1 and the susceptibility of coloreetal cancer among Chinese population were searched in PubMed, EMBase, Cochrane Library, China Biology Medicine disc, VIP database, China National Knowledge Infrastructure and Wanfang database. According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently. Outcomes were pooled with RevMan 5. 1. Results 326 studies were found and 10 clinical controlled trails including 2 983 cases of colorectal cancer and 4 386 cases of healthy objects were included in this analysis. The results of Meta-analysis showed that the lack of GSTT1 gene is associated with colorectal cancer susceptibility （RR = 1.11, 95% CI： 1.06-1.17, Z =4.26, P 〈0.000 1 ）. Conclusion The loss of GSTT1 increase the risk of colorectal cancer among Chinese population.