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肿瘤中Raf激酶抑制蛋白下调机制

Mechanism of Raf kinase inhibitor protein down-regulation in cancer
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摘要 Raf激酶抑制蛋白（RKIP）已被证实在多条蛋白激酶信号通路的调节中发挥重要作用，与肿瘤关系密切。研究表明其在肿瘤中表达下调，机制涉及多方面，包括遗传调控和甲基化、乙酰化、组蛋白修饰、微小RNA调节等表观遗传学调控，并与Snail、NF-κB等蛋白形成环路调节。 Raf kinase inhibiting protein （RKIP） plays a vital role in various physiological processes and participates in multiple signaling pathways, with a close releationgship with tumor. The mechanism of RKIP down-regulation in neoplasms includes transcriptional regulation, methylation, acetylation, histone modifica- tion, microRNA regulation and NF-κB/Snail/RKIP loop regulation.
作者 王韵 李宇红
机构地区 中山大学肿瘤防治中心肿瘤内科华南肿瘤学国家重点实验室肿瘤医学协同创新中心
出处 《国际肿瘤学杂志》 CAS 2015年第10期750-752,共3页 Journal of International Oncology
基金 广东省科技计划（20108080701075）
关键词 磷脂酰乙醇胺结合蛋白质 肿瘤 基因表达调控 Phosphatidylethanolamine binding protein Neoplasms Gene expression regulation
分类号 R730.2 [医药卫生—肿瘤]
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参考文献29

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二级参考文献19

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国际肿瘤学杂志
2015年 第10期

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