人参皂苷的抗肝癌作用机制

Anti-hepatoma mechanisms of ginsenoside

人参皂苷（GS）为人参的主要成分，包括Rg3、Rh2、Rd、Rh1、Rg2等数十种单体。GS及其各种单体抗肝癌机制各异，主要机制包括以下方面：诱导肝癌细胞凋亡、抑制肝癌细胞增殖、抑制肝癌细胞侵袭和转移、逆转肝癌细胞多药耐药、联合其他治疗手段的协同增效作用、提高机体免疫功能、抑制肝脏葡萄糖生成。不同的GS单体通过各自途径发挥不同的抗肝癌作用。

Ginsenosides （GS） as the main ingredient of ginseng, include dozens of monomer, such as Rg3, Rh2, Rd, Rhl, Rg2, etc. GS and various monomers have different anti-hepatoma mechanisms. The main mechanism includes the following aspects, inducing the apoptosis of liver cancer cells, inhibiting the proliferation, invasion and metastasis, reversing the multidrug resistance of liver cancer cells, increasing therapeutic effects by combining with other treatments, improving the immune function of organism and inhibiting hepatic glu- cose production. Different GS monomers play different roles of anti-hepatoma through their respective channels.