成纤维细胞因子21与腹型肥胖早期动脉粥样硬化相关性的研究

Relationship between fibroblast growth factor-21 and early atherosclerosis in patients with abdominal obesity

目的探讨腹型肥胖患者成纤维细胞因子21(FGF-21)与肱踝脉搏波传导速度(baPWV)、肱动脉内皮依赖性舒张功能(FMD)的关系。方法在体检人群中选择腹型肥胖(腹型肥胖组)患者80例及健康人(NGT组)80名,测定FGF-21、baPWV、肱动脉FMD及胰岛素抵抗指数(ln HOMA-IR)、HbA1C、血压及体脂含量(BFT)。结果腹型肥胖组baPWV、FGF-21、ln HOMA-IR高于NGT组(P<0.05或P<0.01),肱动脉FMD低于NGT组(P<0.05),FGF-21水平与BMI、BFT、WHR、TG、ln HOMA-IR、FIns呈正相关(r=0.456、0.355、0.231、0.257、0.218、0.220,P<0.05或P<0.01),Logistic回归分析发现,FGF-21、SBP、ln HOMA-IR是发生动脉粥样硬化(AS)的危险因素(OR=4.720、2.450、2.082,P<0.05)。结论腹型肥胖患者肱动脉FMD下降,而baPWV升高,FGF-21可能对预测其早期AS有意义。

Objective To investigate the relationship between fibroblast growth factor-21（FGF-21）and brachial-ankle pulse wave velocity（baPWV）,brachial artery flow-mediated dilation（FMD）in patients with abdominal obesity. Methods All the participants were divided into two groups：abdominal obesity group（n=80）and NGT group（n=80）.FGF-21,baPWV,brachial artery FMD,ln HOMA-IR,HbA1 c,blood pressure and body fat content（BFT）were measured in both groups. Results BaPWV,FGF-21 and ln HOMA-IR were significantly higher（P 0.05 or P 0.01）,but brachial artery FMD was significantly lower（P〈0.05）in abdominal obesity group than in NGT group.FGF-21 level was positively correlated with BMI,BFT,WHR,TG,ln HOMA-IR and FIns（r=0.456,0.355,0.231,0.257,0.218,0.220,P〈0.05 or P〈0.01）.Logistic regression analysis showed that FGF-21,SBP and ln（HOMA-IR）were associated with AS（OR=4.720,2.450,2.082,P〈0.05）. Conclusion Brachial artery FMD decreases and baPWV increases in patients with abdominal obesity.FGF-21 may be helpful for early AS prediction.