胰岛素的中枢效应及减轻体重的作用

Insulin signaling in central nervous system and weight loss

胰岛素在机体外周和中枢都发挥着重要作用。胰岛素主要通过受体介导转运进入中枢神经系统,作用于下丘脑等位点,发挥调节能量代谢、摄食和体重作用。胰岛素治疗是控制血糖水平的常用手段。地特胰岛素作为新型基础胰岛素类似物,以其安全、有效的作用特点受到关注。与其他胰岛素及类似物相比,地特胰岛素能降低体重增加。本文将对胰岛素的中枢效应及减少体重机制方面的研究进行总结。

Insulin plays a critical role in periphery and central nervous system.It is transported into central nervous system mainly though receptor-mediated pathway insulin regulatess energy homeostasis,food intake and body weight by acting on hypothalamic neuro circuits.Insulin therapy is a common treatment for diabetic patients.Insulin detemir,as a novel basal insulin analog,is getting more and more attentions due to its effectiveness and safety.Compared with other insulins,insulin detemir could significantly reduce body weight gain.In this article,we summarize the progress of insulin signaling in contral nervous system and its effect on weight loss.